TME undergoes dynamic transformation and intercellular interaction, which plays a crucial role in the tumor development [1]. It has been well known that tumor-associated macrophages (TAMs) are recognized as
These data indicate that CCL2/CCR2 signaling occurs independently of TGF-β expression. Recent studies have shown that CCR2 is overexpressed in prostate tumors (69, 70) and that CCL2 signaling promotes human PC-3 prostate cancer cell proliferation and enhances cancer cell survival by autophagic ...
(Arg1, mMGL2, Fiz1, CD163, Retn1a, IL-10, and TGF-beta) compared to those in SE mice (Supplementary Fig. 3A). To explore the influence of EE on CD8+T cells through G-MDSCs and macrophages, primary CD8+T cells were cocultured with polarized G-MDSCs or macrophages in vitro, ...
TGF-beta negatively regulates CXCL1 chemokine expression in mammary fibroblasts through enhancement of Smad2/3 and suppression of HGF/c-Met signaling mechanisms PLoS One, 10 (2015), p. e0135063 CrossrefView in ScopusGoogle Scholar [27] WB Fang, M Yao, G Brummer, D Acevedo, N Alhakamy, ...
For example, tumor-derived TNFα, transforming growth factor beta (TGFβ), and Toll-like receptor 4 ligands lead to recruitment of inflammatory cells to the pre-metastatic lung, which in turn enhance metastatic cell extravasation and survival through expression of factors such as S100A3/4, ...
MagneticLuminex High Performance Assaysare designed for use with the Luminex MAGPIX CCD Imager. Alternatively, kits can be used with theLuminex 100/200™orFLEXMAP 3D, dual laser, flow-based sorting and detection platforms. Analyte-specific antibodies are pre-coated onto color-coded microparticles. ...
PIERCE MA126058 Anti-TGF beta Monoclonal Antibody 250 µg 5225 PIERCE MA126060 Anti-DNA Ligase I Monoclonal Antibody 100 µg 4667 PIERCE MA126061 Anti-RAD17 Monoclonal Antibody 100 µg 4643 PIERCE MA126062 Anti-SHP1 Monoclonal Antibody 100 µg 3539 PIERCE MA126063 Anti-SAA Mono...
(2008) Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med 14: 681–687. [7] Galimberti D, Schoonenboom N, Scheltens P, Fenoglio C, Bouwman F, et al. (2006) Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease. Arch ...
et al. Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: Polyoma middle T transgenic and transplant mouse models of mammary tumor progression. Clin. Exp. Metastasis 28, 351–366. https://doi.org/10.1007/s10585-011-9373-0 (2011). Article CAS PubMed PubMed Central ...
34. de Souza DF, Leite MC, Quincozes-Santos A, Nardin P, Tortorelli LS, Rigo MM, Gottfried C, Leal RB, Goncalves CA: S100B secretion is stimulated by IL-1beta in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway. Journal of Neuroimmunology 2009, 206:52-...