1、通过体内外实验证实,哮喘炎症状态下趋化因子hCCL15、hCCL23和mCCL6表达增加,且主要来源于嗜酸性粒细胞。 2、首次通过实验鉴定mCCL6的受体为G蛋白偶联受体CCR1。 3、通过构建mCCL6基因敲除小鼠,首次发现嗜酸性粒细胞通过CCL6-CCR1信...
《肝癌微环境中CCL15/16-CCR1轴的生物学意义》是依托复旦大学，由王晓颖担任项目负责人的面上项目。项目摘要 受趋化因子系统精密调控的炎症/免疫微环境是影响肝癌转移复发的重要因素。我们前期对肝癌微环境中趋化因子进行全面筛查后发现：CCL15、CCL16特异性高表达，可刺激肝癌细胞，招募CCR1+CD14+炎症细胞，促进肝癌...
Myeloid-derived suppressor cells (MDSC) promotes colorectal cancer invasion through CCL15-CCR1 chemokine axis - Journal of the American College of Surgeonsdoi:10.1016/j.jamcollsurg.2014.07.864Itatani, YoshiroKawada, KenjiSakai, YoshiharuInamoto, Susumu...
In this study, we explored the functional role of eosinophil-derived mCCL6 in the pathology of allergic inflammation. mCCL6 interacts with CCR1, constituting a feedforward loop of asthma exacerbation. The human orthologs of mCCL6, hCCL23, and hCCL15, are also increased in asthma patients, su...
The CCL15 is a human CC chemokine that activates the receptors, CCR1 and CCR3. Unlike other chemokines, it contains an unusually long N-terminal domain of 31 amino acids preceding the first cysteine residue and a third disulfide bond. To elucidate the functional role of distinct structural ...
《CCL15-CCR1轴在调节肝癌侵袭和转移中的作用研究》是依托天津医科大学，由李悦国担任项目负责人的青年科学基金项目。中文摘要 趋化因子及其受体与肿瘤的侵袭、转移及增殖等恶性生物学行为有着密切关系。我们在前期研究发现CCL15在肝癌血清中高表达而在肝癌组织中不表达、在癌旁组织和癌转移的淋巴结组织中高表达，提示...