1、通过体内外实验证实,哮喘炎症状态下趋化因子hCCL15、hCCL23和mCCL6表达增加,且主要来源于嗜酸性粒细胞。 2、首次通过实验鉴定mCCL6的受体为G蛋白偶联受体CCR1。 3、通过构建mCCL6基因敲除小鼠,首次发现嗜酸性粒细胞通过CCL6-CCR1信...
Myeloid-derived suppressor cells (MDSC) promotes colorectal cancer invasion through CCL15-CCR1 chemokine axis - Journal of the American College of Surgeonsdoi:10.1016/j.jamcollsurg.2014.07.864Itatani, YoshiroKawada, KenjiSakai, YoshiharuInamoto, Susumu...
(2004) Functional analysis of chemically synthesized derivatives of the human CC chemokine CCL15/HCC-2, a high affinity CCR1 ligand. J. Pept. Res. 63, 36 - 47Escher SE, Forssmann U, Frimpong-Boateng A, Adermann K, Vakili J, Sticht H, et al. Functional analysis of chemically ...
The definite receptor of mCCL6 has not been precisely defined. A previous study reported that CCR1, which belongs to the G protein-coupled receptor (GPCR) superfamily, is a putative receptor of mCCL6 in IL-13-induced lung inflammation and remodeling models.28Using a GloSensor assay (Fig.5a)...
Eosinophil differentiation and airway inflammation were remarkably decreased by the specific CCR1 antagonist BX471. Thus, the study identifies that the CCL6-CCR1 axis is involved in the crosstalk between eosinophils and HSCs during the development of allergic airway inflammation, which also reveals a ...