Effect of continuous inhibition of MK2i (CC-99677) or p38i (BMS-582949, BIRB-796, SCIO-794) on TNF secretion in LPS-stimulated THP-1 cells. Cells were treated with 0.1 or 1 μM CC-99677 or 1 μM p38 inhibitors for 23 h and then stimulated with LPS for 24 h. TNF secreted into...
Therefore, we profiled the production of 5 key cytokines upon LPS stimulation of human peripheral blood mononuclear cells (PBMCs) in the presence of: the MK2i (CC-99677), two p38 inhibitors (SCIO-469/talmapimod or BMS-582949), or a JAK1/JAK3 inhibitor (tofacitinib). We observed a ...