Therefore, we profiled the production of 5 key cytokines upon LPS stimulation of human peripheral blood mononuclear cells (PBMCs) in the presence of: the MK2i (CC-99677), two p38 inhibitors (SCIO-469/talmapimod or BMS-582949), or a JAK1/JAK3 inhibitor (tofacitinib). We observed a ...
Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibitor under development for