CC-90009 是创的 GSPT1 选择性 cereblon (CRBN) E3 连接酶调节剂,以分子胶的方式作用。CC-90009 通过 CRL4CRBN 选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。 详细内容 公司简介 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
[1] Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. [2] Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation...
CC-90009 is a novel cereblon E3 ligase modulator (CELMoD) currently under investigation in a phase I clinical study in relapsed or refractory acute myeloid... G Lu,C Surka,CC Lu,... - 《Blood》 被引量: 0发表: 2019年 CC-90009, a novel cereblon E3 ligase modulator, targets acute myel...
Eragidomide (CC-90009, CC90009)是一种新型cereblon (CRBN) E3连接酶调节剂,CC-90009与CRL4CRBN结合选择性靶向GSPT1以进行泛素化和蛋白酶体降解。GSPT1是一种小的GTPase,它与翻译终止因子eRF1形成复合物以介导翻译终止。Eragidomide通过促进GSPT1降解可快速诱导急性髓系白血病(AML)细胞凋亡。
产品名称 Eragidomide (CC-90009) 产品规格 5 mg 用途范围 仅做科研,不用于临床 加工定制 否 商品货号 53908ES 商品规格 5 mg 生产厂家 翌圣生物科技(上海)股份有限公司 是否进口 否 规格编码 53908ES08 最小起订量 1.00 发货地 上海 售卖区域 全国 CAS号 1860875-51-9 可售卖地 全国 类型...
此外,在国际范围内,百时美施贵宝公司靶向GSPT1的分子胶类蛋白降解剂CC-90009、雄激素受体(AR)降解剂AR-LDD、针对血液系统恶性肿瘤的CK1α Degrader也正在1期临床阶段中进行探索。 参考资料: [1]中国药物临床试验登记与信息公示平台. Retrieved June 12,2024, From https://www.cde.org.cn/main/xxgk/listpage/...
Treatment of rats with DOCA and salt for 28 days produced a significant increase in systolic blood pressure compared to the control groups which remained normotensive. Rats treated with DOCA expressed greater amounts of the immunoreactive alpha-1 isoform than untreated controls in whole heart ...
The anion transport system of the red blood cell. The role of membrane protein evaluated by the use of 'probes'. doi:10.1016/0304-4157(78)90016-3Z. Ioav CabantchikPhilip A. KnaufAser RothsteinElsevier B.V.BBA - Reviews on Biomembranes ZI Cabantchik,PA Knauf,A Rothstein - BBA - Reviews...
FIBRINOLYSIS/pharmacologyNEOPLASMS/therapyTESTOSTERONE/therapyVASCULAR DISEASESPERIPHERAL/therapyFEARNLEY GR, CHAKRABARTI R.doi:10.1016/S0140-6736(62)90009-0FEARNLEY... FEARNLEY,G - 《Lancet》 被引量: 113发表: 1962年 Monitoring fibrinolysis in whole blood by viscoelastic instruments: A comparison of ROTEM...
Protein 4.2 is a major red blood cell (RBC) protein that interacts with the band 3 protein and with ankyrin. Inherited deficiencies of this protein are associated with spherocytic hemolytic anemia, but the molecular basis of this defect is unknown. We have studied the underlying defect in a ...