CC-90009 是创的 GSPT1 选择性 cereblon (CRBN) E3 连接酶调节剂,以分子胶的方式作用。CC-90009 通过 CRL4CRBN 选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。 详细内容 详细内容 公司简介 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. 网址:www.yeasen.com 第 1 页,共 2 页 Yeasen Biotechnology (Shanghai) Co., Ltd. Hotline:400-6111-883 E-mail: order@yeasen.com [2] ...
产品名称 Eragidomide (CC-90009) 产品规格 5 mg 用途范围 仅做科研,不用于临床 加工定制 否 商品货号 53908ES 商品规格 5 mg 生产厂家 翌圣生物科技(上海)股份有限公司 是否进口 否 规格编码 53908ES08 最小起订量 1.00 发货地 上海 售卖区域 全国 CAS号 1860875-51-9 可售卖地 全国 类型...
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. [2] Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment ...
cells stably expressing the CC-885-sensitive or -resistant GSPT1 variants. Acute myeloblatlic leukemia (AML) cell lines, human liver epithelial cell line (THLE-2) and human peripheral blood mononuclear cells (PBMC) are treated with varying concentrations of CC-885, with IC50s of 10×-6-1 ...
Identification of CC-90009, a novel CELMoD agent that possesses potent anti-AML activity To identify compounds that possess anti-AML activity in a library of cereblon modulators, we performed a CellTiter-Glo cell viability screen in 11 human AML cell lines, peripheral blood mononuclear cells (PBMC...
The trapping, processing, and delivery of nitric (NO) bioactivity by red blood (RBCs) have emerged as a conserved mechanism through which regional blood flow is linked to biochemical cues of perfusion sufficiency. We present here an expanded paradigm for the respiratory cycle based on the coordina...
Protein 4.2 is a major red blood cell (RBC) protein that interacts with the band 3 protein and with ankyrin. Inherited deficiencies of this protein are associated with spherocytic hemolytic anemia, but the molecular basis of this defect is unknown. We have studied the underlying defect in a ...
the glint of the beast-eyes in the starlight, the sting of the steel in his neck, and the rush of blood, the crowd and the cries, the two bodies, his and the Mexican's, locked together, rolling over and over and tearing up the sand, and from away off somewhere the mellow tinkling...
[1] Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. [2] Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation...