响肿瘤DNA损伤修复、DNA复制、细胞凋亡和细胞周期等。故申请人推测CBL0137在抗MM等肿 瘤和克服肿瘤耐药的临床治疗中有着巨大的潜在价值。 发明内容 [0005]本发明的目的是为克服上述现有技术的不足,提供CBL0137及其药学上可接受的 盐在制备抗多发性骨髓瘤药物中的应用。
DNA damageFACTGlioblastomaGlioblastoma (GBM) is an incurable brain tumor with inevitable recurrence. This is in part due to a highly malignant cancer stem cell (CSC) subpopulation of tumor cells that is particularly resistant to conventional treatments, including radiotherapy. Here we show that CBL...
Induction of PANoptosis was associated with Z-DNA formation in the nucleus and likely assembly of PANoptosome. ZBP1 was critical in mediating CBL0137 LPS-induced cell death likely by sensing Z-DNA. Moreover, intraperitoneal administration of CBL0137 plus LPS induced systemic inflammatory responses ...
We saw increased DNA damage when GBM CSCs were treated with CBL0137, as well as a decrease in foci resolution over time, when CBL0137 was combined with irradiation. In order to elucidate if the increase in DNA damage was directly due to the inhibition of the FACT complex, we depleted the...
Novel Anticancer Drug Curaxin CBL0137 Impairs DNA Methylation by Eukaryotic DNA Methyltransferase Dnmt3a. Bioorg. Med. Chem. Lett. 2020, 30, 127296. [Google Scholar] [CrossRef] [PubMed] Lu, K.; Liu, C.; Liu, Y.; Luo, A.; Chen, J.; Lei, Z.; Kong, J.; Xiao, X.; Zhang, S...