BTZ耐药的细胞株中也具有较好的协同作用,CBL0137可能是临床上BTZ耐药的潜在治疗药 物。 [0070]实施例3 [0071]建立了带荧光素酶的ARP1细胞,而后在NCG小鼠尾静脉注射了带荧光素酶的细胞 构建了MM小鼠模型。通过活体成像检测了评估CBL0137和硼替佐米在MM异种移植小鼠模型 ...
在杏仁核原处瘤数学方法中会CBL0137需要有效率消除MYCamp-G3-MB的生长 特异功能性组成员分析显示,CBL0137需要优先消除细胞周期和DNA修复另有统功能性的底物生物学过程。此外,它可通过从启动子区域中会消耗FACT一氧化氮,以选择功能性地损坏MYCamp-G3-MB中会的两个关键致癌特异功能性位点MYC和NEUROD1的特异功能性。
DNA damageFACTGlioblastomaGlioblastoma (GBM) is an incurable brain tumor with inevitable recurrence. This is in part due to a highly malignant cancer stem cell (CSC) subpopulation of tumor cells that is particularly resistant to conventional treatments, including radiotherapy. Here we show that CBL...
Induction of PANoptosis was associated with Z-DNA formation in the nucleus and likely assembly of PANoptosome. ZBP1 was critical in mediating CBL0137 LPS-induced cell death likely by sensing Z-DNA. Moreover, intraperitoneal administration of CBL0137 plus LPS induced syste...
DNA repairFACTMedulloblastomaMedulloblastoma (MB) is a malignant pediatric brain tumor with a poor prognosis. Post-surgical radiation and cisplatin-based chemotherapy have been a mainstay of treatment, which often leads to substantial neurocognitive impairments and morbidity, highlighting the need for a ...
We saw increased DNA damage when GBM CSCs were treated with CBL0137, as well as a decrease in foci resolution over time, when CBL0137 was combined with irradiation. In order to elucidate if the increase in DNA damage was directly due to the inhibition of the FACT complex, we depleted the...
Novel Anticancer Drug Curaxin CBL0137 Impairs DNA Methylation by Eukaryotic DNA Methyltransferase Dnmt3a. Bioorg. Med. Chem. Lett. 2020, 30, 127296. [Google Scholar] [CrossRef] [PubMed] Lu, K.; Liu, C.; Liu, Y.; Luo, A.; Chen, J.; Lei, Z.; Kong, J.; Xiao, X.; Zhang, S...