在杏仁核原处瘤数学方法中会CBL0137需要有效率消除MYCamp-G3-MB的生长 特异功能性组成员分析显示,CBL0137需要优先消除细胞周期和DNA修复另有统功能性的底物生物学过程。此外,它可通过从启动子区域中会消耗FACT一氧化氮,以选择功能性地损坏MYCamp-G3-MB中会的两个关键致癌特异功能性位点MYC和NEUROD1的特异功能性。
We saw increased DNA damage when GBM CSCs were treated with CBL0137, as well as a decrease in foci resolution over time, when CBL0137 was combined with irradiation. In order to elucidate if the increase in DNA damage was directly due to the inhibition of the FACT complex, we depleted the...
Both in vitro and in vivo models were utilized to evaluate the impact of combination therapy on the extent of DNA damage, cell growth, cancer stem cell frequency within tumors, and the ability to prolong survival in mice bearing orthotopic GBM. Radiotherapy after surgery is currently the most ...
DNA repairFACTMedulloblastomaMedulloblastoma (MB) is a malignant pediatric brain tumor with a poor prognosis. Post-surgical radiation and cisplatin-based chemotherapy have been a mainstay of treatment, which often leads to substantial neurocognitive impairments and morbidity, highlighting the need for a ...