Caveolin-1 may function as a negative regulator in majority of tumorigenesis, but in very few tumor it can promote tumorigenesis and metastasis. Thus, lucubrating the role of tumorigenesis and metastasis may provide new idea and develop new pathway for treating tumor. This paper reviews about ...
[2] Nabi I R,Le P U.Caveolae/raft-dependent endocytosis[J].J Cell Biol,2003,161(4):673-677.[3] Sowa G.Caveolae,caveolins,cavins,and endothelial cell function:new insights[J].J Front Physiol,2011,2:120. [4] Schubert W,Frank P G,Razani B,et al.Caveolae-deficient endothelial cells...
caveolaeamlcaveolin一1playallimportantreguatinnaleffectinthetransportofsubstances.endothelialpenneability,thegenensisanddevelopmentofatherosclerosisandsignaltransduction.KeyWOrdS:(]areolae;Caveolin—l;Endothelialcell;PhysiologicalfunctionCaveolae是细胞质膜表面特异性的内陷囊状结构,现已被确认为一种细胞器.它广泛存在于...
近日,来自中国科学院上海巴斯德研究所酒亚明团队在Journal of Molecular Cell Biology(JMCB)在线发表了题为 “Actin nucleator formins regulate the tension-buffering function of caveolin-1”的研究成果,首次揭示了微丝成核蛋白Formin通过调控Caveolin-1缓冲细胞外机械刺激的作用机制(图1)。 图1. Formin通过调控Cave...
依达拉奉通过Ｃａｖｅｏｌｉｎ-１／_ＶＥＧＦ_信号通路促进缺血性卒中大鼠脑血管新生及神经功能修复的作
(P < 0. 05).Conclusion The anti.inf lammation function and glycemic metabolism improvement of glargine may be associated with the expression of Caveoin-1 in skeleta l muscle. 【Key words】 Caveolin.1; Skeletal muscle; Type 2 diabetic mice; TNF一仅; Glargine Caveolin一1是组成细胞膜表面小凹...
Mitochondrial proteases ensure mitochondrial integrity and function after oxidative stress by providing mitochondrial protein quality control. However, the molecular mechanisms that regulate this basic biological function in eukaryotic cells remain largely unknown. Caveolin-1 is a scaffolding protein involved in...
Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Loss of Cav-1 leads to lower adiponectin levels in circulation Cav-1 null mice display a reduced ability to adjust to altered fuel sources Cav-1 null mic... I Wernstedt?Asterholm,D Mundy,W Jian,.....
Effects of Apigenin Regulating Caveolin-1 on Angiotensin 1-7 and Left Ventricular Diastolic Function in Rats with Chronic Heart Failure 在线阅读 免费下载 引用 收藏 分享 摘要 目的:探讨芹菜素通过调控窖蛋白-1(Caveolin-1)对慢性心力衰竭(CHF)大鼠血管紧张素1-7(Ang1-7)及左室舒张功能的机制研究。方法...
Methods: The present study examined physiological caveolae and Cav-1 expression and characterized the function of altered Cav-1 expression in rat aortas with PH. Results: The appearance of caveolae with Cav-1 expression increased significantly in the aortas of rats with PH, but TRPC1 and TRPC6 ...