Additionally, increased hippocampal gliosis and decreased MRI-ROIs were observed in rats exposed to gadolinium. Chronic gadoteric acid and gadobutrol exposure causes hippocampal gliosis and elevates oxidative stress and inflammation in rats. Radiological outcomes are also consistent with these findings. ...
We found that sublethal ferroptotic stress selectively affecting microglia triggers an inflammatory cascade that results in non-cell autonomous neuronal death. Central to this cascade is the conversion of astrocytes to a neurotoxic state. We show that spinal cord tissue from human cases of ALS exhib...
The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis. Despite the extensive use of cuprizone, the mechanism by which it ind
Retina has the highest oxygen consumption rate per tissue volume as compared to other organs, including brain47,48,49. In neonates and adults, the retina is sensitive to ischemia/hypoxia conditions50,51. It is estimated that ~ 60% of adults with acute stroke have visual impairments52. Howe...
Central nervous system targeted autoimmunity causes regional atrophy: a 9.4T MRI study of the EAE mouse model of Multiple SclerosisA. Max Hamilton, Nils D. Forkert, Runze Yang, Ying Wu, James A. Rogers, V. Wee Yong & Jeff F. Dunn Scientific Reports volume 9, Article number: ...
Blast exposure caused reactive gliosis in mouse cerebellum, particularly in the deep cerebellar nuclei. Diffusion tensor imaging tractography of the cerebellum of blast-exposed veterans revealed that mean diffusivity correlated negatively with the number of blast-related mild TBIs. Together, these ...
Neurons were preserved throughout, axonal swelling or beading was not seen, gliosis was minimal, and occasional, scant perivascular macrophage collections were seen. Taken in concert, these findings suggest that the pathological and MRI abnormalities are due to either increased water content of the ...
have reported reduced number of GABA-ergic inhibitory interneuron and activation of microglia and astrocytes in the hippocampus of two-week-old Wwox knockout mice, suggesting pathological involvement of gliosis and neuroinflammation [52]. These results are apparently in contrast to our present data ...
Ortinski PI, Dong J, Mungenast A, Yue C, Takano H, Watson DJ, Haydon PG, Coulter DA (2010) Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nat Neurosci 13(5):584–591. https://doi.org/10.1038/nn.2535 Article CAS PubMed PubMed Central Google Scholar...