The proportion of mediation effects further elucidated the complex dynamics between GM exposure, immune markers, and their combined impact on HSP. Conclusion: The study suggested a causal relationship between GM and HSP, which may be mediated by immune cells.Tian Liang...
Recent studies have shown that the gut microbiota (GM), immune cells, and coronary heart disease (CHD) are closely related, but the causal nature of these relationships is largely unknown. This study aimed to investigate this causal relationship and reveal the effect of GM and immune cells on ...
In recent years, gut microbiota has garnered extensive attention as a potential health-modulating factor, with associations identified between it and various diseases, including RA. This study aims to investigate the causal relationship between gut microbiota and RA using Mendelian Randomization (MR) ...
Gut microbiota is associated with endometrial cancer (EC); however, the causal relationship remains unexplored. This study attempted to explore the relationship between gut microbiota and EC using Mendelian randomization (MR) methods.#In this two-sample MR analysis, we used MiBioGen's gut microbiota...
However, it remains unclear whether gut microbiota serves as a causal factor for COPD or if it is a consequence of the disease. Therefore, we investigated the causal relationship between COPD and gut microbiota, with intention of providing novel insights and references for clinical diagnosis and ...
Background: Numerous inflammatory skin diseases are associated with the gut microbiota. Studies of the association between gut microbiota and inflammatory skin diseases have yielded conflicting results owing to confounding factors, and the causal relationship between them remains undetermined. Methods: Two‐...
Causal relationship between gut microbiota and constipation: a bidirectional Mendelian randomization study. Front Microbiol. 2024;15:1438778. Article PubMed PubMed Central Google Scholar Shirazi A, Stubbs B, Gomez L, Moore S, Gaughran F, Flanagan RJ, MacCabe JH, Lally J. Prevalence and ...
However, the causal association between gut microbiota, associated metabolites, and PAH remains elusive. Added value of this study In this study, we aimed to investigate the causal relationship between gut microbiota, associated metabolites, and PAH and explore whether dietary patterns mediate this ...
Forest plot of the causal relationship between BCa and gut microbiota (A), its functional pathways (B). Notably, Bilophila (OR = 1.38, 95% CI: 1.05–1.80, P = 0.019) was positively associated with BCa (Fig. 3A), suggesting that these bacteria may increase the risk of ...
While several traditional observational studies have suggested associations between gut microbiota and asthma, these studies are limited by factors such as participant selection bias, confounders, and reverse causality. Therefore, the causal relationship between gut microbiota and asthma remains uncertain. ...