However, whether gut microbiota has a causal effect on the development of CKD has not been revealed. Thus, we aimed to analyze the potential causal effect of gut microbiota on the risk of CKD using mendelian randomization (MR) study. Materials and Methods: Independent sin...
Causal effects of gut microbiota-derived metabolites and dietary parameters on PAH Genetically predicted TMAO and its precursors, including betaine and carnitine, were not causally associated with PAH (all P > 0.05). Sensitivity analysis demonstrated consistent results (Table 1 and Supplementary Tabl...
Background: Recent evidence suggests that the gut microbiome and metabolites are intricately involved in Chronic Obstructive Pulmonary Disease (COPD) pathogenesis, yet the precise causal relationships remain unclear due to confounding factors and reverse causation. This study employs bidirectional two-sample...
We performed two-sample bi-directional Mendelian randomization (MR) analysis to investigate the potential causal relationships between gut microbiota and asthma as well as its phenotypes. We also conducted MR analysis to evaluate the causal effect of gut metabolites on asthma. Genetic variants for gut...
The objective of this article is to implement a two-sample MR approach to: [1] assess the causal effects of human serum metabolites on stroke, [2] identify common metabolites with causal effects on multiple stroke subtypes, and [3] identify potential metabolic pathways that may contribute to ...
Therefore, we investigated the causal relationship between COPD and gut microbiota, with intention of providing novel insights and references for clinical diagnosis and treatment. Methods: Based on the genome-wide association study (GWAS) data, we employed MR-Egger regression, random-effects inverse ...
Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2 diabetes (T2D) and obesity1. However, the causal relationships remain largely unresolved. We lev
Conclusion: This study supported that there were beneficial or detrimental causal effects of gut microbiota and its metabolites on autoimmune hypothyroidism risk, which provides more theoretical support for mechanistic research on the "thyroid–gut" axis. 展开 ...
Investigating the causal relationship between the gut microbiome and rheumatoid arthritis: mediating effects of immune cells doi:10.1186/s12967-025-06206-xMendelian randomizationGut microbiotaRheumatoid arthritisImmune cells mediationGenetic predictionsRheumatoid arthritis (RA) is a complex autoimmune and ...
Otherwise, the fixed-effects IVW method was applied. The precision of the IVW method relies on the assumption that all SNPs are valid IVs; hence, its accuracy diminishes when invalid IVs are present. To assess causality, we employed the WME, which requires more than 50% valid IVs to ...