Causal effects of gut microbiota on diabetic neuropathy: a two-sample Mendelian randomization studydoi:10.3389/fendo.2024.1388927GUT microbiomeAUTONOMIC nervous systemGENOME-wide association studiesCONSORTIADIABETIC neuropathiesPOLYNEUROPATHIESObjective: Previous observational studies have sugg...
along with MR Egger, weighted median, simple mode, and weighted mode, for MR analysis to assess the causal effects of gut microbiota on sepsis and other infection-related events [34,35,36,37,38]. The Wald ratio method was used to estimate the effects of each SNP. Cochrane’s Q test wa...
While growing evidence highlights the role of gut microbiota and inflammatory proteins in cancer, with cancer-related inflammation now considered the seventh hallmark of cancer, the direct causal relationships between specific microbiota, cancer, and the potential mediating effects of inflammatory proteins ...
Figure 2. Causal effects of gut microbiota on stroke and subtypes Causal relationships between blood metabolites and stroke and its subtypes Based on the results of the IVW method, we identified a total of 8 metabolites that exhibited causal associations, either positive or negative, with the risk...
Causal effects of gut microbiota on asthma As shown in Table 1, the results of IVW analyses indicated that the genetically predicted relative abundance of genus Lachnospiraceae_UCG001, genus Butyricimonas, and genus Oxalobacter were causally associated with a higher risk of asthma, while class ...
We also examined the mediation effects of gut microbiota in the associations between PM2.5 exposure levels and neuropsychiatric disorders, using two-step MR analyses. Results Each 1 standard deviation (1.06 ug/m3) increment in PM2.5 concentrations was associated with elevated risk of ASD (odds ...
Conclusion This study supported that there were beneficial or detrimental causal effects of gut microbiota and its metabolites on autoimmune hypothyroidism risk, which provides more theoretical support for mechanistic research on the "thyroid–gut" axis. 展开 ...
The treatment effects are heterogenous across patients due to the differences in their microbiomes, which in turn implies that we can enhance the treatment effect by manipulating the patient’s microbiome profile. Then, the coadministration of microbiome
Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2 diabetes (T2D) and obesity1. However, the causal relationships remain largely unresolved. We lev
The study observed interactions between gut microbiota and male reproductive health, noting that the causal relationships were previously unclear. It aimed to explore the potential cause-and-effect relationship between gut bacteria and male reproductive problems such as inflammation, infertility, and sperm...