Among the nanoparticles used in medicine, we highlight cationic solid lipid nanoparticles (SLN). Given their nontoxic properties, much research has focused on the beneficial effects of SLN for drug or gene delivery system. However, little attention has been paid to the adverse impacts of SLN on...
SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines. ...
Lipid nanoparticles (LNPs) can be used as delivery vehicles for nucleic acid biotherapeutics. In fact, LNPs are currently being used in the Pfizer/BioNTech
Cationic lipidsare often used in combination with a co-lipid to formliposomes,nanoemulsionsorsolid lipid nanoparticles. 4.28.4.3.1Cationic liposomes Liposomes are spherical vesicles formed ofphospholipidsby self-assembly through lipids energetic interactions in the size range of 20nm to the micron.Cationi...
Lipid-based nanoparticles for cancer treatment Lipid Nanocarriers for Drug Targeting Book2018, Lipid Nanocarriers for Drug Targeting Mohammad A. Obeid, ... Valerie A. Ferro Explore book 8.3.1.2.1 Cationic liposomes Cationic liposomes are produced using lipids that induce a positive charge on the sur...
Lipid-Polymer Hybrid Nanoparticles as a New Generation Therapeutic Delivery Platform: A Review Lipid–polymer hybrid nanoparticles (LPNs) are core–shell nanoparticle structures comprising polymer cores and lipid/lipid–PEG shells, which exhibit comp... K Hadinoto,A Sundaresan,WS Cheow - 《European ...
Solid lipid nanoparticles (SLNs) consisting of tristearin or tribehenin, and monoolein aqueous dispersions (MADs) consisting of glyceryl-monoolein have been studied as potential nanocarriers for nucleic acids. The cationic character of nanocarriers was obtained by adding cationic surfactants, such as diis...
Maier et al., “Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics,” Molecular Therapy, (2013), 21(8):1570-1578. Primary Examiner: O DELL, DAVID K Attorney, Agent or Firm: Daiichi Sankyo Company, Limited (Denver, COLORADO, US) Claims...
13. The combination product according to claim 12, wherein said nanoparticles are selected from cationic polysaccharide nanoparticles, especially from cationic maltodextrin nanoparticles such as porous maltodextrin with or without a lipid core nanoparticle such as NP+ or DGNP, or from PLA or PGA or ...
Two novel cationic lipids based on protonated cyclen and steroid (cholesterol or diosgenin) moieties with carbamate linkage have been designed and synthesized for gene delivery. Cationic liposomes were easily prepared from each of these lipids individually or from the mixtures of each cationic lipid ...