and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B,L and H,cathepsin S shows a ...
Cathepsin S overexpression lysate was created in HEK293 Cells and intended for use as a Western blot (WB) positive control. Purification of Cathepsin S protein from the overexpression lysate was verified. Cathepsin S cDNA Clones (52) Cathepsin S cDNA clones are full length sequence confirmed and...
Suppression of immune response via inhibition of cathepsin SHidde L.P., Chapman H.A., Riese J.R., Bryant R.P., Bogyo S.M. Inhibitor of cathepsin S based upon peptide sequence which comprises at least about 2-20 consecutive residues from preferred invariant chain cleavage site of cathepsin...
1.3.1Cathepsins Cathepsinsare proteolytic proteins, which act as signaling molecules and have different functions. The classification ofCathepsinsis based on structure,catalytic mechanism, and substrate. Based on thehuman genomedraft sequence, the mainCathepsincategories are serine (Cathepsin A and G),...
Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy 来自 掌桥科研 喜欢 0 阅读量: 44 作者:Y Jiang,Woosley, Alec N,N Sivalingam,S Natarajan,Howe, Philip H 摘要: Jiang et al. show that Disabled-2 (Dab2) regulates the switch between autophagy and apoptosis in TGB...
Fig. 2. CatK-induced cleavage products of SDF-1α. (A) Amino acid sequence of SDF-1α and the cleavage sites by CatK at pH 5.5 and/or pH 7.4. Cleavage sites are indicated by arrows and the secondary structure elements are shown above the amino acid sequence. (B) Three-dimensional ...
Using liquid chromatography-mass spectrometry, to our knowledge, we report the first peptide cleavage map of the lysosomal degradation process of α-syn. Studies of purified mouse brain and liver lysosomal extracts and individual human cathepsins demonstrate a direct involvement of cysteine cathepsin B...
The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D[1]. 分子量 1816.15 Formula C87H126N22O21 Sequence MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-{Lys(Dnp)...
Elastase cleavage of PAR2 at S68↓V69 induces PAR2-dependent activation of extracellular signal regulated kinases 1/2 (ERK1/2) by a Rho-kinase dependent pathway (34) that is distinct from trypsin-induced MAPK activation that is mediated by β-arrestins (36). Potential biased agonists of ...
Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D. Krafft, Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-β by cathepsin D, J Biol Chem 269 (1994), 18422-18428... US Ladror,SW Snyder,GT Wang,... - 《Journal of Biological Chemis...