The deduced 895-amino acid protein has a calculated molecular mass of 100 kD and contains 3 vinculin homology domains. It shares about 57% amino acid identity with other alpha-catenins. PCR detected CTNNA3 expression mainly in heart and testis. Lower amo
Alpha-catenin in HeLa human cervical cancer cells was labeled using mouse anti-α-catenin and visualized with Alexa Fluor® 488 goat anti-mouse IgG (green). Filamentous actin was visualized using red-fluorescent Alexa Fluor® 63...
doi:10.1038/ncb2700Siew-Ping HanAlpha S. YapNature Cell BiologyHan S-P, Yap AS. An α-catenin deja vu. Nat Cell Biol 2013; 15: 238-239.Han, S., & Yap, A. S. (2013). An α-catenin deja- vu. Nature Cell Biology, 15(3), 238-239....
Expression of n-cadherin and alpha catenin in astrocytomas and glioblastomas. Br. J. Cancer 72, 627-633.Shinoura, N., N. E. Paradies, et al. (1995). "Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas." Br J Cancer 72(3): 627-33....
(BMD), can regulate the onset and progression of bone diseases in human osteoblasts by regulating Axin1 through GATA4 and estrogen receptor alpha (Erα) binding (Suthon et al.2022). Further studies by Yoshinori Matsumoto et al. found that deficiency of the E3 ubiquitin ligase RNF146 leads ...
[8]Ekert JO,Gould RL,Reynolds G,et al.TNF alpha inhibitors in Alzheimer's disease：A systematic review[J].Int J Geriatr Psychiatry,2018(33)：688-694.[9]Zheng C,Zhou XW,Wang JZ.The dual roles of cytokines in Alzheimer's disease：update on interleukins,TNF-a,TGF-p and IFN-y[J]....
Epithelial-mesenchymal transition (EMT) induced by TNF-alpha requires AKT/GSK-3beta-mediated stabilization of snail in colorectal cancer. PLoS One. 2013;8(2):e56664. CAS PubMed PubMed Central Google Scholar Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer ...
Rubinfeld B, Souza B, Albert I et al (1995) The APC protein and E-cadherin form similar but independent complexes with alpha catenin, beta-catenin, and plakoglobin. J Biol Chem 270(10):5549–5555PubMedCrossRef 23. Smits R, Kielman MF, Breukel C et al (1999) Apc1638T: a mouse mod...
These results suggest that E-cadherin and alpha-catenin undertake important roles as intercellular adhesion molecules; their preserved expression is associated with a better overall survival rate in synovial sarcoma and may have prognostic value. Abnormal levels of beta-catenin, with or without mutation...
3Evidence-based medicine has further proved that the abnormal activation of this signaling showed non-negligible effects on cancer-associated mortality.4,5,6Despite these broad acknowledgments of the significant impact of Wnt/β-catenin signaling on cancers, advances in targeted therapies remain largely...