(2012). The cytoskeletal protein alpha-catenin unfurls upon binding to vinculin. The Journal of Biological Chemistry, 287, 18492-18499.Rangarajan ES, Izard T (2012) The cytoskeletal protein alpha-catenin unfurls upon binding to vinculin. J Biol Chem 287:18492-18499...
1), although simultaneous binding of α-catenin to E-cadherin, β-catenin, and actin was not reported. The involvement of α-catenin in cancer was first studied in cell lines derived from human cancers; for example the lung cancer cell line PC-9 was found to have a homozygous deletion of...
assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell ...
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structural molecule activity protein binding beta-catenin binding vinculin binding poly(A) RNA binding gamma-catenin binding cadherin binding actin filament binding cadherin binding involved in cell-cell adhesion structural constituent of cytoskeleton non-motor actin binding protein 参与通路 ova...
"AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion."J. Cell Sci. 114:3177-3188(2001) [PubMed] [Europe PMC] [Abstract]. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong...
αT-Catenin: a novel tissue-specific β-catenin-binding protein mediating strong cell-cell adhesion Although originally discovered in testis, αT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis ... Barbara Janssens,Steven Goossens,Katrien ...
BACKGROUND: Osteopontin (OPN) is a secreted Ca(2+)-binding phosphoprotein able to mediate cell attachment to bone via an RGD sequence and the alpha v beta ... CA Lopez,JR Hoyer,PD Wilson,... - 《Laboratory Investigation》 被引量: 178发表: 1993年 Invited Review: A Contemporary Overview ...
The canonical Wnt/β-catenin signaling pathway initiates by the binding of the Wnt ligand to its receptor, Frizzled (FZD), and the LDL receptor-related proteins 5 or 6 [29, 32,33,34]. As a consequence, the cytoplasmic protein Disheveled (Dvl) is phosphorylated and the detachment of β-...
T. (2011). JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion. FASEB J 25, 613-623.Lee M.H., Padmashali R., Koria P., Andreadis S.T. JNK regulates binding of α -catenin to adherens junctions and cell-cell adhesion. FASEB J. 2011; 25 :613–623...