Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart. Deletion of either CASQ2 or HRC results in relatively mild phenotypes characterized by preserved cardiac structure and function...
Sildenafil and FDP-Sr attenuated the abnormal expression of these molecules (P<0.01). Testosterone ameliorated CASQ2 and SERCA2a mRNA expression but had no effects on their protein expres- sion. Testosterone had no effects on both mRNA and protein expression of FKBP12.6 (Figure 6). CASQ2 mRNA...
6. Rollins, M. F. et al. Structure reveals a mechanism of CRISPR-RNA-guided nuclease recruitment and anti-CRISPR viral mimicry. Mol. Cell 74, 132–142 e135 (2019) 7. Zhang, Z., Pan, S., Liu, T., Li, Y. & Peng,...
参考文献 1. Makarova, K.S. et al. Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.Nat Rev Microbiol18, 67-83 (2020). 2. Ozcan, A. et al. Programmable RNA targeting with the single-protein CRISPR effector Cas7-11.Nature597, 720-725 (2021)....
Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart. Deletion of either CASQ2 or HRC results in relatively mild phenotypes characterized by preserved cardiac structure and function...