Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart. Deletion of either CASQ2 or HRC results in relatively mild phenotypes characterized by preserved cardiac structure and function...
This is explained by the existence of >60 highly conserved anionic Asp and Glu residues in a protein of ∼400 amino acids (Yano and Zarain-Herzberg 1994). Figure 4b shows a three-dimensional model of human CASQ2 that we have constructed using rabbit skeletal muscle calsequestrin structure ...
6. Rollins, M. F. et al. Structure reveals a mechanism of CRISPR-RNA-guided nuclease recruitment and anti-CRISPR viral mimicry. Mol. Cell 74, 132–142 e135 (2019) 7. Zhang, Z., Pan, S., Liu, T., Li, Y. & Peng,...
Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart. Deletion of either CASQ2 or HRC results in relatively mild phenotypes characterized by preserved cardiac structure and function...