Catecholamine-induced polymorphic ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations. To define how CASQ2 mutations cause CPVT, we produced and studied mice carrying a human D307H missense mutation (...
Recent evidence has suggested that low serum testosterone, as seen in male hypogonadism, is an independent risk factor for cardiovascular disease (CVD) due to increased inflamma- tory factors and cytokines in the myocardium[13]. Testosterone replacement therapy (TRT) has become an attractive inter...