Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix Eur. J. Neurosci. 2006 23 129 – 140Bravarenko NI,Onufriev MV,Stepanichev MY,etc.Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix.[J].2006,1...
CASPASE-LIKE ACTIVITY IS ESSENTIAL FOR LONG-TERM SYNAPTIC Fo ee r R ev r Fo Pe er Re vieIs, Caspaselike ActivityFor, Essential
Cells were pretreated with Ac-DEVD-CHO, an inhibitor of caspase-3-like activity, and submitted to X-rays at doses ranging from 1 to 4 Gy. Our results show that the inhibition of caspase-3-like activity prevents completely the appearance of the classical hallmarks of apoptosis such as ...
CASPASE-1-LIKE ACTIVITY: VACUOLAR PROCESSING ENZYME Vacuolar Processing Enzyme (VPE) is a plant protease localized in the vacuole and responsible for processing vacuolar proteins. Hatsugai et al. (2004) reported that VPE, in addition to its activity against the tetrapeptide ES...
Results: We show that VPEγ binds in vivo to a general caspase inhibitor and to caspase-1-specific inhibitors, which block the activity of VPEγ. A cysteine protease inhibitor, cystatin, accumulates to 20-fold higher levels in vpeγ mutants. Homologs of cystatin are known to suppress hypersens...
This cyclized protein contains a caspase-3 cleavage site and acquires fluorescent activity only after cleavage by activated caspase-3-like proteases. Using this tool, we measure in real-time apoptosis of each cell under various culture conditions without any addition and damaging sample. Results ...
Caspases play a very important role in initiating and executing apoptotic processes in animal cells. In this study we show that plant mitochondria were able to initiate the activation of caspase 3 in a Xenopus cell free system. Caspase 3-like activity was found to be present in plant cells ...
Unlike in leukemia cells, bortezomib mainly inhibited the caspase-like activity of the proteasome in cervical cancer cells. Nelfinavir exhibited no effects on proteasomal activity in cervical cancer cells and leukemia cells. Although both bortezomib and nelfinavir acted on cisplatin-resistant cervical ...
The caspase-like activity DEVDase was measured by using the fluorescent substrate Ac-DEVD-AMC and antibodies against the human caspase-3 active enzyme cross-reacted with bands, the intensity of which paralleled the activity. All the environmental stresses tested produced a substantial increase in ...
Accumulating evidence in recent years suggests the existence of caspase-like activity in plants and its functional involvement in various types of plant PCD, although no functional homologs of animal caspases were identified in plant genome. In this mini-review, we will cover the recent results on...