进一步分析,caspase-8的活性水平受到明显上调,并且出现其对应激活亚基片段,并且活性缺失的caspase-8突变体无法介导这一进程的发生。由此可知,这一死亡过程为caspase-8活性依赖型的细胞焦亡过程。至此,作者证实,α-KG具有介导caspase-8-GSDMC依赖性的细胞焦亡事件。 α-KG也是常见的ROS诱导试剂,可以有效上调ROS的水平。作...
Caspase cleaves target proteins downstream of an Asp residue. Given that the in-gel migration of the N-terminal cleavage product of GSDMC indicated that its molecular weight is approximately 35 kDa (Fig.1c), the potential Asp site of α-KG-induced caspase-8-mediated cleavage in GSDMC may ...
Studies have indicated that PD-L1 can transform TNFα-induced apoptosis into pyroptosis, mediating an atypical pathway of pyroptotic cancer cell death through the caspase-8/GSDMC pathway, resulting in tumor cell death [255]. Furthermore, research has discovered that caspase-8-mediated pyroptosis ...
进一步分析,caspase-8的活性水平受到明显上调,并且出现其对应激活亚基片段,并且活性缺失的caspase-8突变体无法介导这一进程的发生。由此可知,这一死亡过程为caspase-8活性依赖型的细胞焦亡过程。至此,作者证实,α-KG具有介导caspase-8-GSDMC依赖性的细胞焦亡事件。 α-KG也是常见的ROS诱导试剂,可以有效上调ROS的水平。作...
The DR6 receptosome herein provides a platform for the cleavage of GSDMC by active caspase-8, thereby leading to pyroptosis. Moreover, this α-KG-induced pyroptosis could inhibit tumor growth and metastasis in mouse models. Interestingly, the efficiency of α-KG in inducing pyroptosis relies on...