由于先前的研究表明,PKA可以磷酸化caspase-11以抑制其激活36,灯盏乙素是否能在PKA特异的位点增加caspase-11的Ser/Thr磷酸化还需要进一步的研究[共识的RRXS*/T*基序可以被PKA磷酸化在丝氨酸(S*)/苏氨酸(T*)残基上,精氨酸(R)在3位,任何...
2022年4月29日,来自美国康奈尔大学的Julien Moretti及其团队在Nat Immunol (IF: 20.479)杂志上发表名为Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome的研究[1]。 主要结果 mRNAb...
Caspase-11 activation is independent of ASC and NLRC4.N. Casson, CierraM. Copenhaver, AlanE. Zwack, ErinNguyen, Hieu TStrowig, TillJavdan, BaharP. Bradley, WilliamC. Fung, ThomasA. Flavell, RichardE. Brodsky, Igor
2022年4月29日,来自威尔康奈尔医学院炎症性肠病研究所的微生物学和免疫学教授Julie Magarian Blander研究团队在Nature immunology杂志发表了文章“Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome”,从活的革兰氏阴性细菌中检测到vita-PAMP mRNAbac协同LPS可触发NLRP3...
[2] Horn, Sebastian., Hughes, Michelle A., Schilling, Ramon., Sticht, Carsten., Tenev, Tencho.. Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival. Cell reports, 2017, 19(4):785-797. ...
Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and development of renal interstitial fibrosis in vivo and in vitro. Mice were subjec...
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection 文献摘要: 病毒感染会诱发宿主的天然免疫应答,产生各种细胞因子,例如IFN-I,激活炎性小体,触发感染细胞的程序性死亡。严格调控炎性细胞因子的产生对于控制感染的同时又不损伤宿主,有着重要的意义。作者...
[2] Horn, Sebastian., Hughes, Michelle A., Schilling, Ramon., Sticht, Carsten., Tenev, Tencho.. Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival. Cell reports, 2017, 19(4):785-797.[3] ...
凋亡起始者(caspase 2和10)的活化属于同性活化(Homo activation)。caspase 8和10含有串联重复的“死亡效应子”结构域(death effector domain,DED),而caspase 2和9则含有不同但类似的caspase募集结构域(caspase recruitment domain CARD),这两种结构域是募召caspase 2,8和10所必需的。