Because SBM may contribute to cartilage breakdown in OA, experimental OA was induced in dogs by transecting the anterior cruciate ligament of the knee and ... C Behets,JM Williams,D Chappard,... - 《Journal of Bone & Mineral Research》 被引量: 719发表: 2004年 Effects of bisphosphonate on...
6.The cartilage in such areas is almost inextensible. 这些部位的软骨几乎一点儿也不能伸展。 7.It is caused by a breakdown in the cartilage that protects the ends of the bones, as well as the growth of new bone around the joint as the body tries to repair the damage. ...
Furthermore, their severity and prevalence were associated with tibiofemoral osteophytes, increased tibial bone area, decreased knee cartilage volume, and increased type II collagen breakdown.1 Knee cartilage defects were predictive of knee cartilage loss at the medial tibia9 during 2 years, suggesting...
Bredella MA, Tirman PF, Peterfy CG et al (1999) Accuracy of T2-weighted fast spin-echo MR imaging with fat saturation in detecting cartilage defects in the knee: comparison with arthroscopy in 130 patients. AJR Am J Roentgenol 172:1073–1080 PubMed CAS Google Scholar Masi JN, Sell CA,...
It was reported that the widespread and severity of knee cartilage defects goes up with increasing age and body mass index associated with tibiofemoral osteophytes, increased tibial bone area, decreased knee cartilage volume and increased type II collagen breakdown. In addition, weight loss may help...
in the progressive remodelling of affected joints. The available data have shown that the molecular steps in cartilage matrix breakdown overlap in OA and RA. However, they have also, to a great extent, changed our view of the roles of cartilage in the pathogenesis of these disorders. In OA,...
Thus a fine balance exists between anabolism (synthesis) and catabolism (tissue breakdown) with ongoing tissue remodelling part of the normal healthy process. Interesting facts Articular cartilage has no blood or neural supply and relies on diffusion of nutrients and waste products through the ...
significantly reduceMMP1but increaseTIMP1gene expression and protein levels [98]. In rats with synovial arthritis, DHT treatment has reduced TNFα and MMP2 levels [99]. These data indicate that DHEA is associated with reduced inflammation and modulation of collagen breakdown in both rats and ...
Finally, the evening mea- surements (4 hours after the second dosing, 3 hours after dinner), showed a clear and significant (r = 0.54, p < 0.0001) correlation between changes in CTX-I and CTX- Discussion Ample evidence of a concomitant breakdown of bone and cartilage is found in the...
surface and allows joints to move freely through older adulthood.1,2Years ofmicrotrauma, isolated instances of more severe joint trauma, and aging of the cartilaginous tissue eventually result in a breakdown of articular cartilage, which contributes to the development ofosteoarthritisfor many older ...