A strong, flexible connective tissue that is found in various parts of the body, including the joints, the outer ear, and the larynx. In the early development of most vertebrates, the skeleton forms as cartilage before most of it hardens into bone. ...
Chondrocytes vary in shape, size and number of cells per area depending on their different anatomical locations, even within different regions of the normal knee joint. Close to the surface they are flatter, smaller and generally have a greater density than the cells deeper in the matrix. Each...
Compared with the knee joint, the femoral head articular surface has a higher ratio of cartilage coverage, reduced extent of weight-bearing area, vulnerable blood supply, and deeper location; hence, it is much more difficult to repair. Current reparative surgical techniques for osteochondral injuries...
2). By optimizing the untranslated region and chemical modification of FGF18 mRNA, we constructed a synFGF18 mRNA delivery system that can stably express therapeutic doses of FGF18 protein and sustain expression in the knee joint cavity of mice for more than 6 days. LNP-FGF18 mRNA can ...
When OA model mice were administered an intra-articular knee injection of an adenoviral vector encoding a miR-760 mimic construct, cartilage ECM degradation was aggravated. Conversely, the overexpression of HBEGF in OA model mice partially reversed the effects of miR-760 overexpression, restoring ...
To establish a time-lapse chondrocyte dedifferentiation model, we cultured primary hyaline chondrocytes isolated from uncalcified cartilage in knee joints of newborn mice32,33 and replated each passage after doubling the cell quantity (seeding density: 2.4 × 104 cells per cm2; collecting density...
The analyses resulted in two systems of assessing severity of chondropathy: SFA scoring for the three compartments of the knee, which is a continuous variable, and SFA grading, which is a semiquantitative variable. These systems seem to be of clinical relevance. However, more studies are ...
1d). To explore the regenerative and immunomodulatory potential of IMRCs, we used the synovial fluids from four donors with meniscus injuries (Supplementary Table 1) to mimic the actual micro-environment in the knee joint cavity and established a cell model for in vitro assessment and mechanism ...
Another tissue structure that attracts considerable attention is the meniscus present in the knee because of its susceptibility to permanent traumatic damage. It is made of fibrocartilaginous tissue having unique biomechanical and shock absorption properties. Meniscus damage predisposes the patient to osteoar...
Graft hypertrophy of matrix-based autologous chondrocyte implantation: a two-year follow-up study of NOVOCART 3D implantation in the knee Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 22 (2014), pp. 1329-1336 CrossrefView in ScopusGoogle Scholar [24] S. Andere...