The carnitine shuttle pathway is altered in patients with neovascular age-related macular degeneration. Investig. Ophthalmol. Vis. Sci. 2018, 59, 4978-4985. [CrossRef]Mitchell, S.L.; Uppal, K.; Williamson, S.M.; Liu, K.; Burgess, L.G.; Tran, V.; Umfress, A.C.; Jarrell, K.L....
The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration 来自 国家科技图书文献中心 喜欢 0 阅读量: 64 作者: SL Mitchell,K Uppal,SM Williamson,K Liu,LG Burgess,VL Tran,AC Umfress,KL Jarrell,JN Cooke Bailey,A Agarwal 展开 摘要: Improved analytical...
l-carnitine has a variety of roles in fatty acid metabolism, the most important of which is to participate in the classical “carnitine shuttle” process [20]. Specifically, l-carnitine facilitates β-oxidation by transporting medium- and long-chain fatty acids into the mitochondria [47]. l-...
Overdose of valproic acid does not produce a readily identifiable toxidrome, but it may deplete hepatic L-carnitine stores, impairing mitochondrial transport via the carnitine shuttle. Therefore, L-carnitine has been considered a potential antidote to restore mitochondrial function, reduce production of...
(or Krebs cycle). Increasing levels of acetyl-CoA through either pathway has the potential to strongly deplete the levels of CoA needed in the mitochondrial matrix for beta oxidation of fatty acids. The carnitine shuttle system described above acts as a buffer for excess mitochondrial acetyl-CoA ...
2.2SCFAs – revisiting the carnitine shuttle Carnitinehas also been proposed to have an important buffering role to regulate the amount of CoA that is acyl-bound or free to engage additional substrates (e.g. Ref.[51]), and also has antioxidant properties by virtue of its ability to scavenge...
VPA acyl-CoA esters formed in the cytosol by oxidation enter the mitochondria via the carnitine shuttle. VPA-related toxicity results from the accumulation of some toxic metabolites, which may result from the misbalance between the intra-mitochondrial β-oxidation and the microsomal ω-oxidation, in...
The oxidation of medium- (C6–C10) and short-chain (C4–C6) fatty acids seems largely independent from the carnitine shuttle [19], [66]. Under physiologic conditions, oxidation of long- and medium-chain fatty acids is primarily handled by the mitochondrial β-oxidation system, with only ...
re-imported into the mitochondria for beta-oxidation (Futile Cycle). ALCAR, shuttled to the nucleus (shown in violet), can be used as source of acetyl groups for histone acetylation, probably contributing to lipid metabolism-specific gene expression ...
(Patel, Nemeria, Furey, & Jordan, 2014). FA acyl-l-carnitine derivativesare also shuttled into mitochondria and catabolized by β-oxidation (Houten & Wanders, 2010;Kastaniotis et al., 2017). For even-chain FAs, a repeated four-step cycle cleaves two carbon atoms at a time from the ...