[0020] The subject of the invention described herein are carnitine derivatives of general formula (I) in optically active form of absolute configuration (R) or (S) 2 [0021] where [0022] Y is an OR or NR1R2 group with [0023] R equal to hydrogen, C1-C10 alkyl or alkyl substituted...
Caco-2 CellsIntracellular FluidHumansCalciumEgtazic AcidFluorescein-5-isothiocyanateDextransDecanoic AcidsThe mechanism of paracellular expansion by absorption enhancers, e.g., EDTA, sodium caprate (C10), and decanoylcarnitine (DC), was studied, the focus being on the process of actin microfilament ...
Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cellsdoi:10.1021/js9504604The mechanism of paracellular expansion by absorption enhancers, e.g., EDTA, sodium caprate (C10), and decanoylcarnitine (DC), was studied, the focus being on the process of actin ...
Initial metabolic studies indicated severe non-ketotic C6-C10 dicarboxylic aciduria, plasma carnitine deficiency, and a characteristic elevation of plasma C:16:0, C18:1, and C18:2 acylcarnitine species. Enzyme assay confirmed deficiency of CACT activity. Molecular studies indicated that this child ...