Diamanti K, Cavalli M, Pan G, et al.: Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes. (2019) Sci Rep. | doi:10.1038/s41598-019-45906-5 Ghonimy A, Zhang DM, Farouk MH, Wang Q.: The Im...
investigated. Theoxidationof fatty acids at all chain lengths from C10:0 (decanoate) to C24:0 (lignocerate) is defective in patients with congenitalCACT deficiency, suggesting that CACT is required for mitochondrial transportation of fatty acyl moieties longer than 10 carbon atoms (Chalmers...
Urine organic acid analysis shows dicarboxylic aciduria that affects C6-C10 fatty acids, suggesting that CACT deficiency may compromise the oxidation of these fatty acids (Iacobazzi et al., 2004). Plasma acyl-carnitine profile is similar to CPT2 deficiency and reveals low concentrati...
Liver function, assessed by Child-Pugh score, was significantly correlated with the blood level of each carnitine fraction measured (C0, C2, C3, C4, C6, C10, C12, C12:1, C14:1, C16, C18:1, and C18:2-acylcarnitine). Cirrhotic symptom score was significantly correlated with C0, C2, C3...
(C8), decenoylcarnitine (C10:1), decadienoylcarnitine (C10:2), malonylcarnitine (C3DC), methylmalonylcarnitine (C4DC), glutarylcarnitine (C5DC), hexadecenoylcarnitine (C16:1), 3-Hydroxy butyrylcarnitine (C4-OH), and 3-Hydroxy oleylcarnitine (C18:1-OH) carnitine levels in FMF patients ...
Absorption‐enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco‐2 cells The mechanism of paracellular expansion by absorption enhancers, e.g., EDTA, sodium caprate (C10), and decanoylcarnitine (DC), was studied, the focus being... M Tomita,M Hayashi,S Awazu - 《Journal of...
Type 2 diabetes is a highly prevalent chronic metabolic disorder characterized by hyperglycemia and associated with several complications such as retinopathy, hyperlipidemia and polyneuropathy. The dysregulated fatty acid metabolism along with tissue lipid accumulation is generally assumed to be associated in ...
Height C18:1 carnitine levels were also determined in carnitine palmitoyltransferase-2 [28], carnitine-acylcarnitine translocase [29], long-chain acyl-CoA dehydrogenase deficiencies [30]. Clark-Taylor and Clark-Taylor have been stated that C10:1, C14:2 and C14:1 for plasma acyl-carnitine profile...
(3S)-3-[(2-carboxyacetyl)oxy]-4-(trimethylaminio)butanoate 1-Propanaminium, 3-carboxy-2-[(2-carboxyacetyl)oxy]-N,N,N-trimethyl-, inner salt, (2S)-[ACD/Index Name] Malonyl-L-carnitine Malonylcarnitine O-malonyl-D-carnitine Unverified ...
C10 (decanoyl) MCAD deficiency C12 (dodecanoyl) GA type II C12-OH (3-hydroxy dodecanoyl) LCHAD deficiency C14:1 (tetradecenoyl) CACT, CPT II, VLCAD, LCHAD deficiency C14 (myristoyl) CACT, CPT II, VLCAD, LCHAD deficiency C16 (palmitoyl) CACT, CPT I, CPT II, VLCAD, LCHAD deficiency C16...