Ipecac, an over-the-counter emetic agent, has been a drug of choice for abuse by patients with eating disorders. Its alkaloid emetine has been associated with serious cardiac toxicity; however, the dose effect has not been well established. We present a patient with anorexia and bulimia ...
Digoxin is the drug of choice in established atrial fibrillation and amiodarone the drug of choice in paroxysmal atrial fibrillation and ventricular arrhythmia. Non-sustained ventricular tachycardia occurs in 20% of patients and is the single best predictor of sudden death in adults. Sustained ...
mechanisms have been proposed, including drug binding by intercalation into the DNA of cardiac muscle cells; inhibition of several enzyme systems; and promotion of peroxidative damage, mediated by free radicals, to cell membranes, mitochondrial membranes, DNA, enzymes and membranes of sarcoplas...
antiarrhythmic drug treatmentimplantable cardioverter defibrillatorArrhythmias in Hypertrophic Cardiomyopathy.Arrhythmias, particularly atrial fibrillation and nonsustained ventricular tachycardia, are common in adult patients with hypertrophic cardiomyopathy. Atrial fibrillation has long been thought to herald an ...
Alcohol intake may also interfere with the drug and dietary treatment of hypertension. This altogether supports a causal relationship between alcohol consumption and a hypertensive state. Alcoholic cardiomyopathy: Cytotoxicity of alcohol on heart muscle The 1989 landmark report of Urbano-Marquez et al. ...
Several studies have confirmed the protective effects of miR-21 against cardiovascular diseases. miR-21 can improve fibrosis and apoptosis of cardiomyocytes; moreover, the hypoglycemic drug vildagliptin exerts hypoglycemic and cardioprotective effects through the miR-21/SPRY1/ERK/ mammalian target of rapam...
miR-21 can improve fibrosis and apoptosis of cardiomyocytes; moreover, the hypoglycemic drug vildagliptin exerts hypoglycemic and cardioprotective effects through the miR-21/SPRY1/ERK/ mammalian target of rapamycin pathway [93]. The p38/ mitogen-activated protein kinase (MAPK) signaling pathway is ...
Polyneuropathy is uncommon (33), but has implications based on current drug approval indications (see the Emerging Therapies section). As in wtATTR-CM, there appears to be a male preponderance, with only 25% of reported cases being women (34). The true penetrance of this mutation is unknown...
The Changing Face of Teenage Drug Abuse — The Trend toward Prescription Drugs history of emotional stress, absence of coronary lesions, a low CK peak and rapid recovery of left ventricular function, Tako-Tsubo cardiomyopathy was ... RA Friedman - 《New England Journal of Medicine》 被引量: ...
His past medical history was unremark- able and he had no history of alcohol or drug abuse and no family history of heart disease. ECG displayed sinus tachycardia and left ventricular hypertrophy. The patient's kidney, liver, and thyroid function tests were normal. His NT-proBNP was elevated ...