Biophysics Designing New Drugs to Treat Cardiac Arrhythmia PORTLAND STATE UNIVERSITY Jonathan Abramson YeYanpingHeart failure resulting from different forms of cardiomyopathy is defined as the inability of the heart to pump sufficient blood to meet the body's metabolic demands. It is a major disease ...
Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The concept is appealing because of potentially lower development costs and shorter timelines than are needed to pr
The FDA recently approved 2 drugs for adults with cardiomyopathy caused by transthyretin-mediated amyloidosis (ATTR), a rare and life-threatening disease. The oral medications, tafamidis meglumine and tafamidis, are the first to receive ... F Sancar - 《Jama the Journal of the American Medical ...
Avoid activity where sudden loss of consciousness could cause serious risk to patient or others (e.g., driving automobile, operating complex machinery, swimming, climbing).Myocarditis, Cardiomyopathy, and Mitral Valve IncompetenceMyocarditis and cardiomyopathy, sometimes fatal, reported. Although these ...
testicular damage due to anabolic steroid use counteraction testosterone and epistestosterone production stimulation Side Effects: abnormal body changes acromegaly antibody formation arthritis brain damage brain swelling cardiomyopathycoma congestive heart failure coronary artery disease Cruetzfeldt-Jakob disease dea...
Allergy to corn or corn products or Constrictive pericarditis (a heart disease) or Pericardial tamponade (a heart disease) or Restrictive cardiomyopathy (a heart disease)—Should not be used in patients with these conditions. Diabetes or Hypertrophic cardiomyopathy (a heart disease) or Hypotension (...
We also found strong perturbations in KEGG cardiovascular-specific pathways: cardiac muscle contraction (P 5 2.54E-11, rank: 3rd among 12 stat- istically detectable associations), dilated cardiomyopathy (P 5 1.74E-10, rank: 5th), arrhythmogenic right ventricular cardiomyo- pathy (P 5 2.33E-10...
In a diabetic cardiomyopathy rat model, argatroban treatment reduced plasma levels of glucose and cholesterol, alleviated ventricular dysfunctions by improving systolic and diastolic functions, decreased cardiac fibrosis, and reduced...
With respect to verapamil (PRR 1.83 (1.07–3.12); after unmasking PRR 0.79 (0.75, 0.82); n.s.), in most cases, the reason behind this prescription was not specified, whilst in one report, the medication was used to treat hypertrophic cardiomyopathy. The mean age mentioned in these reports...
Today, many medicinal plants are known to be used in alternative medicine in many countries around the world to treat both types of diabetes, but the list of official antidiabetic drugs based on them is insufficient. A promising raw material for the creation of antidiabetic drugs of natural or...