The HL-1 cell line, a mouse cardiac muscle cell line, is derived from the AT1 mouse atrial cardiomyocyte tumor lineage24. HL-1 cells were used for ChIP assays and cellular functional assays. Before induction of hypoxia in cells, the medium was replaced with a sugar-free and serum-free ...
Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients. Somatic gene editing by sequence-specific nucleases offers new options for restoring the DMD reading frame, resulting in expression of a shorten...
Cardiorespiratory Fitness and Muscle Strength Changes in Vo2 max differed between groups (P = .003) (Table 2); Vo2 max increased 219 mL/min (95% CI, 104-334) in the endurance training group and remained unchanged in the no exercise control group (−92 mL/min [95% CI, −229...
Gulch, RW, Jacob, R (1975) Length-tension diagram and force-velocity relations of mammalian cardiac muscle under steady-state conditions. Pflügers Arch 355: pp. 331Gülch, R., Jacob, R. (1975) Pflüg. Arch. 355: pp. 331-346Gülch RW, Jacob R (1975) Length-tension diagram and force-...
The composite end point of MAEs comprised (1) all-cause death; (2) myocardial injury (creatinine kinase muscle-brain isoenzymes, CK-MB, at least 10 times the upper reference limit, ie, 70 μg/L on the first postoperative morning); (3) new-onset of acute heart failure or low output ...
Fig. 1. A CONSORT diagram depicting enrollment flow, drop-outs, and reasons for drop out. Baseline characteristics The characteristics of both groups are shown in Table 1. The two groups were very similar with no significant differences in age, sex, racial composition, anthropomorphic and metaboli...
Delivering pacing pulses at multiple LV sites is more likely to capture a larger volume of cardiac muscle and therefore the site of latest electrical activation within the LV may be more likely to be depolarized early, resulting in superior resynchronization. Multisite LV stimulation may also more...
Structural heart defects at birth, lesions in blood vessels, heart valve calcification over time, heart muscle inefficiency for various reasons and electrical signal conduction abnormalities are all examples of cardiac diseases anyone can experience throughout their lifetime. The Centers for Disease ...
A total of 350 different exosomal miRNAs (exo-miR) were found, and bioinformatic analysis defined more than 2200 genes as potential targets of exo-miR, including Actin Alpha Cardiac Muscle 1 (ACTC1) and Calcium Voltage-Gated Channel Subunit Alpha1 C (CACNA1C), regulated with high probability...
Ventricular fibrillation is often inducedasa result of a heart attack but may also beinduced by accidental electric shock or due tosevere stress such as in the case of surgical oper-ations, drowning, or the like.The most effective treatment used to restoreanormal rhythm toa heart muscle ...