Even highly specific, localized disturbances of the delicate equilibria of cell functions can lead rapidly to a picture of generalized cell damage or cell necrosis. Various subcellular organelles of cardiac muscle cells subject to specific damage by toxic agents include: 1. Mitochondria: Compounds that...
are considerably shorter with much smaller diameters. Cardiac muscle also demonstrates striations, the alternating pattern of dark A bands and light I bands attributed to the precise arrangement of the myofilaments and fibrils that are organized in sarcomeres along the length of the cell. These...
A detailed picture of the membrane organisation of the cardiac muscle cell underpins our understanding of how the electrical impulse, generated within the heart, stimulates coordinated contraction of the cardiac chambers. This article highlights, with the aid of modern cellular imaging methods, key ...
(abdominal pain, fevers, and increased liver function enzymes), or viremia. It may also present a sepsis-like picture that can progress to multiple organ failure. CMV infection has been associated with acute cellular rejection and an increased frequency and severity of chronic rejection (Dunc...
Cardiac norepinephrine stores and the contractile state of heart muscle. Circ Res. 1966;19:317–25. Article CAS PubMed Google Scholar Lakatta EG, Gerstenblith G, Angell CS, Shock NW, Weisfeldt ML. Diminished inotropic response of aged myocardium to catecholamines. Circ Res. 1975;36:262–9...
In this way we could unveil molecular mediators of cardiac hepcidin actions in protecting the cardiac muscle during reperfusion injury. It has to be mentioned that this is not the first time that hepcidin is linked with beneficial actions outside the classical role in controlling iron load in ...
Why current passes rapidly through the Purkinje system? Purkinje cells are larger in size. The cells are present along the axis of the current There are more gap junctions between the cells. The diameter of the cell is more. RMP of these cells is -90mV. ...
Takayasu arteritis is a chronic systemic vasculitic syndrome that involves the wall of the aorta and the large elastic arteries. TA occurs mainly in young female adults under the age of 40 [1,2]. The pathology of TA features chronic giant cell vasculitis of the aorta and its main branches ...
cardiac adipocyte mesenchymal cell fibroblast pericyte smooth muscle cell Introduction Aberrant accumulation of adipocytes in hearts may affect cardiac functions. For example, ventricular rupture during acute myocardial infarction has been shown to be more common in the fatty heart (Roberts and Roberts, 19...
Titin (connectin) is a giant protein that forms a single-molecule elastic filament extending from the M-line to the Z-line in the striated muscle sarcomere. The sequence of titin consists mainly of repeats of two types of ~100-amino acid motifs (class I and class II that show homology ...