are considerably shorter with much smaller diameters. Cardiac muscle also demonstrates striations, the alternating pattern of dark A bands and light I bands attributed to the precise arrangement of the myofilaments and fibrils that are organized in sarcomeres along the length of the cell. These...
However, the production of lactate is not confined to anaerobic conditions but occurs even in resting state with aerobic conditions, and lactate is metabolized in healthy heart, brain, liver, skeletal muscle, and kidney, though to a lesser degree than during hypoperfusion [7]. In experimental ...
A detailed picture of the membrane organisation of the cardiac muscle cell underpins our understanding of how the electrical impulse, generated within the heart, stimulates coordinated contraction of the cardiac chambers. This article highlights, with the aid of modern cellular imaging methods, key ...
SA Node works as a pacemaker because it has a tendency to undergo depolarization spontaneously. In SA Node, cell have leaky Na+ channels, when Na+ enters into cell, the RMP cannot really rest because incoming Na+ will take RMP towards the threshold when RMP reaches up to the threshold, th...
The patient might have had a late-presenting ST-segment elevation myocardial infarction with the development of a systolic murmur after presentation. Both ischemic papillary muscle rupture and ventricular septal rupture are mechanical complications of myocardial infarction. Intraprocedural TEE showed mild-to...
Cardiospheres CM, SM, EC CM, SM, EC Yes After myocardial infarction, cardiosphere derived cell infusion into the coronary arteries decreased infarct size and improved ventricular function 86,107 Abbreviations: CM, cardiomyocyte; SM, smooth muscle cell; EC, endothelial cell; EPDC, epicardium-derived...
Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug cardiotoxicity as well as for therapeutic discovery. Challenges still exist in obtaining the complete capability of in situ sensing ...
Picture it as an Independence Day movie. The climatic music plays. The humans are desperately readying their defenses as they brace for the aliens’ final attack. With absolute dread, they look to the sky at the message that the aliens have just streamed: ‘We had...
5c) and “regulation of cardiac muscle cell action potential” (NES = −1.59, FDR < 0.016, Fig. 5d). This analysis corroborated the scRNA-seq results on the repression of the predicted direct targets of miR-365 (KCNQ1, KCNJ2, and KCNJ3), but also revealed downregulation of ...
Light chain (AL) (primary systemic) amyloidosis is a hematologic disorder of plasma cells (plasma cell dyscrasia) related to, albeit different from, multiple myeloma. It is caused by the proliferation of an abnormal clone of plasma cells that overproduce lambda (80%), or less commonly kappa...