AmyloidosisShock, cardiogenicMortalityHeart failureCardiomyopathyBackground: Cardiac amyloidosis is an underdiagnosed cause of heart failure. The mean survival rate without treatment is low, signifying the importance of early diagnosis. The prognosis depends on the time of diagnosis and the severity of the...
CLEVELAND, Ohio – First-line treatment with the proteasome inhibitorbortezomib(Velcade, Millennium Pharmaceuticals) plusdexamethasoneand an alkylating agent (BDex+AA) improves survival in patients with symptomaticheart failuredue to amyloid light-chain (AL)amyloidosis, a rapidly fatal disease, new researc...
Independent Predictors of Survival in Primary Systemic (AL) Amyloidosis, Including Cardiac Biomarkers and Left Ventricular Strain Imaging: An Observational... The prognostic value of Doppler myocardial imaging, including myocardial velocity imaging, strain, and strain rate imaging, in patients with primary...
Cardiac magnetic resonance imaging:CMR has evolved as a key test in diagnosing cardiac amyloidosis. It helps differentiate amyloidosis from hypertensive heart disease and sarcoidosis. Additionally, it provides information about tissue characterization and helps detect early cardiac amyloidosis. However, it ca...
Epigallocatechin-3-gallate tolerability and impact on survival in a cohort of patients with transthyretin-related cardiac amyloidosis. A single-center retrospective study. Intern Emerg Med. 2018;13(6):873–80. https://doi.org/10.1007/s11739-018-1887-x. Article PubMed Google Scholar Download ...
The natural history of the disease, involvement of other organs, and treatment options vary significantly based on the protein of origin. In AL amyloidosis, amyloid protein is derived from immunoglobulin light chains, and most often involves the kidneys and the...关键词:...
Cardiac involvement is present in about 70% of patients with AL amyloidosis at the time of diagnosis, and the severity of cardiac involvement is the main determinant of overall survival in this patient population.1 Measurement of B-type natriuretic peptide (NT-proBNP) and troponin T or I, ...
Daratumumab in first-line treatment of patients with light chain amyloidosis and Mayo stage IIIb improves treatment response and overall survival. Haematologica. 2023;109:220. PubMed Central Google Scholar Dispenzieri A, Gertz MA, Kyle RA, Lacy MQ, Burritt MF, Therneau TM, Greipp PR, ...
Importantly, there was no survival benefit for patients with an ICD compared with those without, despite the high rate of VA. On the other hand, Donnellan et al. [35] studied advanced ATTR-CA patients who had a primary prevention implantable cardioverter-defibrillator (ICD) and found that ...
Predictive Value of Assessing Diastolic Strain Rate on Survival in Cardiac Amyloidosis Patients with Preserved Ejection Fraction Since diastolic abnormalities are typical findings of cardiac amyloidosis (CA), we hypothesized that speckle-tracking-imaging (STI) derived longitudinal ea... L Dan,H Kai,S ...