Amyloidosis is a disease of protein misfolding that ultimately impairs organ function. Previously, we demonstrated that amyloidogenic light chains (κ1, λ6, and λ3 subtypes), internalized by cardiac fibroblasts, enhanced sulfation of secreted glycosaminoglycans. In this study, we investigated the ...
Amyloid deposits are most frequently found in the interstitial space, which are seen in a cross-sheet structure [2]. The amyloid deposits in AL amyloidosis are predominantly pericellular and reticular, frequently extending to more than 40% of the myocardial tissue, and may contain inflammatory infi...