CARDIAC amyloidosisIMMUNOELECTRON microscopyAmyloid is an amorphous, fibrillar material formed from various abnormally folded proteins that deposits locally or systemically. Over 95% of cases have been attributed to light chain deposition (AL) or transthyretin deposition (ATTR) amyloidosis. The basic ...
Cardiac amyloidosis is caused by the extracellular, interstitial deposition of misfolded protein deposits or amyloid fibrils that result in a restrictive cardiomyopathy with associated conduction system and rhythm disturbances. This family of diseases has distinct prognoses and treatment options depending on ...
Upon further workup, an echocardiogram revealed strain patterns suggestive of cardiac amyloidosis and bone marrow biopsy confirmed the diagnosis of multiple myeloma. Unfortunately, despite starting treatment with steroids and chemotherapy, the patient succumbed to his condition in a matter of weeks. We ...
In the diagnosis of monoclonal gammopathy, serum or urine protein electrophoresis was not sensitive enough to be used clinically compared to serum free light chain assay (35.8% vs. 96.4%). CONCLUSION: In systemic amyloidosis, cardiac involvement was the most important determinant of the prognosis, ...
Aim of this study is the analysis of clinical, morphologic and haemodynamic features of cardiac amyloidosis. Cardiac amyloidosis was demonstrated histologically in 7 of our patients: in 6 by endomyocardial biopsy during cardiac catheterization, in one at autopsy. The clinical picture was characterized ...
noninvasive diagnosispyrophosphate scintigraphyIntroduction: Cardiac amyloidosis is a disorder caused by the accumulation of abnormal protein products, amyloid, in the myocardium which subsequently impairs normal heart function. Heart failure with preserved ejection fraction has been increasingly attributed to ...
Major Subject Heading(s)Minor Subject Heading(s) Amyloidosis [diagnostic imaging] Humans Myocardium Tomography, X-Ray Computed PreMedline Identifier: 36255317From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.Printer...
Amyloidosis occurs when the body produces abnormal proteins that bind together to form a substance called amyloid. Amyloids can deposit in any tissue or organ, including the heart, kidneys, liver and nerves. When it occurs in the heart, it's called cardiac amyloidosis. Dr. Martha Grogan, a M...
The heart is commonly involved in various forms of amyloidosis and cardiomyopathy is a major cause of morbidity and mortality in these patients. Diagnosis of cardiac amyloidosis is often delayed due to nonspecific presenting symptoms and failure to recognize early signs of amyloid heart disease on rou...
This unusual finding called into question the diagnosis of AL amyloidosis and highlights the importance and difficulty of determining the cause of cardiac amyloid deposition before initiating treatment. We review the different forms of cardiac amyloidosis and propose a diagnostic algorithm to help identify...