The diagnosis of cardiac amyloidosis was confirmed upon analysis of endomyocardial biopsy results. The patient was subsequently diagnosed with and treated for underlying plasma cell myeloma and later died of cardiac arrest. This atypical presentation of cardiac amyloidosis underscores the need to consider ...
TRANSTHYRETIN (TTR) CARDIAC AMYLOIDOSIS WITH TYPICAL ECHOCARDIOGRAPHY FINDINGS AND BIOPSY RESULTS P Tewari - Elsevier 被引量: 0发表: 2019年 Contemporary Reviews in Cardiovascular Medicine Transthyretin (TTR) Cardiac Amyloidosis F. Ruberg,J. Berk 被引量: 0发表: 2012年 A transgenic model of human ...
9 A cardiac biopsy is often needed in such patients to obtain a definitive diagnosis.8 Hereditary transthyretin amyloidosis The transthyretin (TTR) gene is located on chromosome 18 and contains four exons and five introns. There are more than 120 mutations in the TTR gene, most of which encode...
Once the diagnosis of cardiac amyloidosis is established, the nature of the precursor can be ascertained by either subcutane- ous fat aspiration or endomyocardial biopsy with mass spec- trometry of the sample or staining of the tissue with Congo red and antibodies specific for individual ...
Results Different precursors cause different forms of cardiac amyloidosis with different outcomes and therapeutic options. Cardiac involvement determines not-specific symptoms and the diagnosis remains often a challenge for cardiologists. As a consequence, patients continue to present end-stage heart failure...
Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation 2016;133:2404‐12. Article CAS PubMed Google Scholar Dorbala S, Ando Y, Bokhari S, Dispenzieri A, Falk R, Ferrari VA. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in ...
A cardiac biopsy was performed and results were positive for cardiac amyloid deposition. He was started on a β‐blocker, irbesartan, and diuretics, and he underwent cardiac rehabilitation therapy for 3?months, which failed to improve his functional status. The patient continued to have diarrhea ...
Results Four long-term survivors with cardiac amyloidosis and regression of cardiac features on TTE were identified. Mean age was 60 years and average survival was 139 months from the time of diagnosis of cardiac involvement. Statistically significant regression of the cardiac features of cardiac amylo...
Cardiac amyloidosis (CA) is increasingly recognized as an underlying cause of heart failure with preserved ejection fraction (HFpEF), associated with high morbidity and mortality. However, most studies, solely investigated the prevalence of CA in special subgroups including HFpEF and severe aortic valve...
A positive result for myocardial biopsy, cardiac MRI or PYP scan was considered to be diagnostic and the date of whichever study came first defined as the diagnosis date. For cases where providers noted a strong suspicion of amyloidosis on TTE before subsequent confirmation by another modality, ...