5.7c or 5.7d) then either has a slope of −1 in the acidic region joined to a flat line extending into the basic region (specific acid catalysis) or a flat line in the acidic region joined to a line with slope 1 in the basic region (specific base catalysis). In some cases, only...
Saponification of carboxylic, phosphonic or phosphoric acid derivs. with LiOH in an aq. medium is effected in the presence of a metal cpd. (I).DRAUZ KARLHEINZ PROF DRMUELLER THOMAS DRKOTTENHAHN MATTHIAS DRSEEBACH DIETER PROF DRTHALER ADRIAN DR...
Hydrolysis of the carboxylic acid ester yields II.Alternatively, the reaction between VI and V can be performed in the presence of a transition metal based catalyst with a suitable ligand and a suitable base and in a suitable solvent, at a suitable temperature such as from room temperature to...
2-((2S,3R,4S,6R)-6-(buta-2,3-dien-1-yl)-4-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)acetic acid (4) To a stirred solution of 8 (2.0 g, 8.3 mmol, 1.0 equiv.) in a mixture of THF/H2O/MeOH (64 ml, 2:1:1 v/v) was added LiOH∙H2O (1.4 g, 33.2 mmol, 4.0 equiv....
diaminodicarboxylic acid derivs. of formula (I) by opt. mixed Kolbe synthesis comprises dissolving a protected amino acid derv. of formula (II) with a protected amino acid derv. of formula(III) in a solvent R<4>OH or in a heterocyclic or in a heterocyclic or aliphatic solvent contg. \...
Acetonides are also obtained in a two-step reaction scheme in which an acid halide and 1,2-aminoalcohol are reacted in an ether solvent in the presence of LiOH to form a hydroxyamide, which is then reacted with 2-alkoxypropene or 2,2-dialkoxypropane in the presence of acid to form ...
CONSTITUTION:A lactam(5-13 membered ring lactam, its oligomer, or its polymer through ring opening) is hydrolyzed in the presence of LiOH at 60-300 deg.C to prepare a lithium salt of an omega-aminoalkanecarboxylic acid. The reaction solution is saturated with CO2 introduced, Li2CO3 is ...
DL-2-pyrrolidone- 5-carboxylic acid may be converted into its lithium salt by, for example, reacting DL-PCA with a water-soluble lithium compound, such as LiOH, in water. This salt may then be resolved into the optically active enantiomorphs thereof by contacting a saturated or supersaturated...
mixed Kolbe synthesis comprises dissolving a protected amino acid derv. of formula (II) with a protected amino acid derv. of formula(III) in a solvent ROH or in a heterocyclic or in a heterocyclic or aliphatic solvent contg. \\- 1 hetero atom, or in an mixt. of such solvents, ...
CONSTITUTION:An alpha-halogenocyclohexanone such as 2-chlorocyclohexanone, alpha- bromocyclohexanone or alpha-iodocyclohexanone is brought into contact with a base such as LiOH, NaOH, Na2CO3 in the presence of water and an organic solvent such as methanol (0.5-10 times the amount of the starting...