It further relates to a process for producing carboxylic acids, characterized by reacting an olefin with carbon monoxide and water in the presence of a catalyst having an acid strength within the range of -9.2 SIMILAR -6.0 and ... H Kawasaki,H Miwa,O Ichihara 被引量: 0发表: 1987年 ADHESI...
Reacting olefin with carboxylic aciddoi:US4447642 AA process for preparation of alkyl carboxylate mixtures enriched in alpha-methylalkyl carboxylate compounds, by reaction of an olefin and a carboxylic acid compound in the presence of a mordenite catalyst.Lewis B. Young...
disadvantage of the oxazolines is that they retain reactivity towards alkylating reagents. On the other hand, this forms the basis for an alternative deprotection in the presence of acid sensitive structures. Aftermethylationthe oxazolines can be hydrolyzed to the free acids with 2 M NaOH (94% ...
Preparing aromatic carboxylic acid derivatives by aromatic nucleophilic substitution, comprises reacting aromatic carboxylic acid derivatives with metal co... Preparing aromatic carboxylic acid derivatives by aromatic nucleophilic substitution, comprises: reacting aromatic carboxylic acid derivatives or its salts.....
US5863949 Mar 7, 1995 Jan 26, 1999 Pfizer Inc Reacting carboxylic acid derivative with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzenetriazole and hydroxylamine; treats diseases involving production of tumor necrosis factor in a mammal...
- It can be used to prepare pharmacologically active compounds such as antibacterial drugs, anti-tumor drugs and other bioactive molecules. Preparation: Tert-butyl esters of -4-bromoindole-1-carboxylate are usually prepared by reacting 4-bromoindole-1-carboxylic acid with tert-butyl ammonium bromide...
Thus, for example, 7-amino-3-vinyl-3-cephem-4-carboxylic acid is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-(methoxycarbonyl)-methoxyimino acetate in tetrahydrofuran and water at 4° C. in the presence of triethylamine. The reaction mass is extracted ...
Prepn. of 2-oxazoles of formula (I) comprises reacting a carboxylic acid deriv. of formula (II) with an aminoacetal of formula (III) and then cyclising the obtd. amidoacetal condensation prod. of formula (IV) in polyphosphoric acid. R1 = aryl or 1-21C (cyclo)alk(en)yl; R2, R3,...
The present invention relates to quinolone carboxylic acid derivatives having useful antibacterial activities of formula (I): ##STR1## wherein, R1, R2, and R3, which may be the same or different, are each hydrogen or a halogen atom, or a lower alkyl group optionally substituted with an ami...
However, water can also be used in the reaction of II with guanidine, using a base such as, for example, NaOH as a solvent. If L=Cl, the reaction is advantageously carried out with addition of an acid scavenger, e.g. in the form of excess guanidine for removing the hydrohalic acid...