Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry[J] . Engy Shokry,Fabio Villanelli,Sabrina Malvagia,Anna Rosati,Giulia Forni,Silvia Funghini,Daniela Ombrone,Maria Della Bona,Renzo Guerrini,Giancarlo...
A LC-MS/MS method for therapeutic drug monitoring of carbamazepine, lamotrigine and valproic acid in DBS Background:Therapeutic drug monitoring of antiepileptic drugs in children with epilepsy assists for personalized drug therapy but require numerous patient visits for venous blood sampling. DBS is an...
Therapeutic drug monitoring/range: Usual Therapeutic Range: 4 to 12 mcg/mL (17 to 50 micromol/L)Monitoring of blood levels may be particularly useful in cases of dramatic increase in seizure frequency; during pregnancy; when treating children or adolescents; in suspected absorption disorders; for...
carbamazepine-10,11-epoxidechemiluminescence immunoassayhigh-performance liquid chromatographytherapeutic drug monitoringBackground: Carbamazepine is a first-choice ... P Gillery,KJ Lackner,G Lippi,... - 《Clinical Chemistry & Laboratory Medicine》 被引量: 22发表: 2009年 Micellar electrokinetic capillary ...
Therapeutic Drug Monitoring (TDM) Philip A.Routledge,Alun D.Hutchings, inThe Immunoassay Handbook (Fourth Edition), 2013 Carbamazepine SeeFig. 9. Sign in to download full-size image FIGURE 9.Carbamazepine. Clinical Applications Carbamazepineis an anticonvulsant used in the treatment of partial and sec...
Therapeutic drug monitoring may be useful for optimizing dosage, minimizing toxicity and adverse effects, and verifying drug compliance. Withdraw gradually in patients with seizure disorders to minimize potential for increased seizure frequency and status epilepticus. (See Discontinuance of Therapy under ...
Carbamazepine Abstract The pharmacokinetic characteristics of carbamazepine are described and the interaction effects of concomitant antiepileptic drugs on carbamazepine in terms of its pharmacokinetics and pharmacodynamics are highlighted. Therapeutic Drug Monitoring Unit Department of Clinical and Experimental ...
Salivary levels of anticonvulsants: a practical approach to drug monitoring. Neurology 27: 409–413, 1977 PubMed CAS Google Scholar McKauge L, Tyrer JH, Eadie MJ. Factors influencing simultaneous concentrations of carbamazepine and its epoxide in plasma. Therapeutic Drug Monitoring 3: 63–70, ...
Therapeutic Function Analgesic, Anticonvulsant Biological Functions Carbamazepine has become a major drug in the treatment of seizure disorders. It has high efficacy, is well tolerated by most patients, and exhibits fewer long-term side effects than other drugs. Oral absorption of carbamazepine is qui...
therapeutic drug monitoring by determining its concentration in serum or plasma. A narrow therapeutic index necessitates an accurate and reliable means for the measurement of carbamazepine concentration in human serum or plasma. Due to the narrow therapeutic index, the increasing number of carbamazepine ...