carbamazepineepilepsyLC/MStherapeutic monitoringTDMBackground: Carbamazepine (CBZ) has complex pharmacokinetic properties leading to fluctuation in plasma level, which requires routine therapeutic drug monitoring (TDM) to ensure its efficacy and prevent adverse effects. The objective of this study is ...
Individualization of drug dose with the help of plasma level detection is a must in case of Carbamazepine therapy. TDM helps better outcome by minimizing the risk of under or overdosing due to drug/food interaction or genetic polymorphism of enzymes and transporters involved in the metabolism of ...
The serum level approach to individualization of diphenylhydantion (DPH) therapy in epilepsy is well established. When universally applied it may help to reveal causes of inappropriate therapeutic responses. We report here a high rate of therapeutic failure with DPH in epileptic children, with widespr...
Carbamazepine is also another drug that increases the autophagic flux and protects normal tissues against radiation (Kim et al, 2011), presumably due to restoration of the radiation-induced autophagy blockage (Zois et al, 2011). Restoring apoptosis Another important approach aside to autophagy death ...
Exposure was defined with respect to co-medication including one of five agents known for their capacity to induce (phenytoin, phenobarbital and carbamazepine) or to inhibit (thioridazine and levomepromazine) the metabolism of psychotropic drugs. 87 patients exposed to such co-medication were matched...
Empty Cell Carbamazepine Potential weak interaction Empty Cell Itraconazole No interaction expected Empty Cell Phenobarbital Potential weak interaction Empty Cell Amiodarone No interaction expected Empty Cell Phenytoin Potential weak interaction Empty Cell Montelukast No interaction expected – No interactio...
(valproic acid, carbamazepine, topiramate) and in patients with liver or renal failure. Blood cultures should be sent if bacteremia is a clinical concern since multifocal septic emboli can present as encephalopathy and COVID-19 patients are at risk for superimposed bacterial infections. Thyroid ...
Carbamazepine is also another drug that increases the autophagic flux and protects normal tissues against radiation (Kim et al, 2011), presumably due to restoration of the radiation-induced autophagy blockage (Zois et al, 2011). RESTORING APOPTOSIS Another important approach aside to autophagy death ...
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main... adequately be used for the therapeutic drug monitoring of the considered antiepileptic drugs, carbamazepine, oxcarbazepine, eslicarazepine acetate, and...
example, this effect may be related to bipolar disorder prophylaxis (Rapoport, 2008b) since a similar reduction in AA signalling has also been observed with other structurally independent bipolar disorder treatments such as lithium (Basselin et al., 2005) and carbamazepine (Bazinet et al., 2006...