When converting from oral to IV therapy, administer corresponding total daily IV dosage (equivalent to 70% of the total daily oral dosage) in 4 equally divided 30-minute infusions at 6-hour intervals.Bioequivalence demonstrated between oral carbamazepine and 30-minute IV infusions of the drug. IV...
Methods Patients receiving a stable oral dosage of carbamazepine were switched to an intravenous (IV) carbamazepine formulation solubilized in a cyclodextrin matrix (at a 70% dosage conversion) for either a 15- or a 30-min infusion every 6h for up to 7days and then switched ...
Oral bioavailability of CBZ from N-Gly-CBZ appears to be greater than from CBZ per se in rats.; The in vivo conversion of N-cysteamine-CBZ appeared to be instantaneous and quantitative following IV administration to rats, probably due to reaction with glutathione. The pharmacokinetic profiles of...
In addition, the conversion of the glass to the crystalline dihydrate form occurred on a similar time-scale in humid environments at room the temperature, as water was absorbed from the atmosphere. 2.1. Nuclear Magnetic Resonance Spectroscopy Solution state NMR of the as-received carbamazepine (...