Response to CAR T cell therapy can be explained by ecological cell dynamics and stochastic extinction eventsdoi:10.1101/717074Gregory J. KimmelFrederick L. LockePhilipp M. AltrockCold Spring Harbor Laboratory
Patient responses to autologous CD19 chimeric antigen receptor (CAR) T-cell therapies are limited by insufficient and inconsistent cellular functionality. Here, we show that controlling the precise level of stimulation during T-cell activation to accommo
CAR is composed of an extracellular domain for tumor antigen recognition, in which the variable regions of the heavy and light chains of an antibody are connected by a flexible linker to form a single-chain variable fragment (scFv), and an intracellular domain for triggering T cell activation,...
CAR T本身就是T细胞，因此让CAR T攻击T细胞会造成CAR T细胞自相残杀。
CAR T-cells are a form of adoptive cell therapy that has demonstrated remarkable success in treating hematological malignancies. While preclinical and clinical models provide encouraging results, treatment of solid cancers using CAR T-cell therapies remain limited. Solid tumors present a unique set of...
Molecular Cancer (2023) 22:100 https://doi.org/10.1186/s12943-023-01799-7 Molecular Cancer RESEARCH Open Access Homology‑independent targeted insertion (HITI) enables guided CAR knock‑in and efficient clinical scale CAR‑T cell manufacturing Hyatt Balke‑Want1, Vimal Keerthi1, ...
A T cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ, γ, and ζ, but the contributions of different CD3 chains remain elusive. Using quantitative mass spectrometry, we simultaneously quantitated the phosphorylation of the immunoreceptor tyrosine-based activation ...
Leaving a store, I returned to my car only to find that I had locked my keys and cellphone inside. A teenager riding his bike saw me 1 a tire (轮胎) angrily. “What’s wrong?” he asked. I explained my 2 .“But even if I could call my wife,” I said, “she can’t bring ...
analyses of anticancer therapies; however, several advanced extrapolation techniques (e.g., mixture cure models, spline-based models) have been established and implemented to account for the potentially curative nature of novel treatments, including chimeric antigen receptor T cell (CAR-T) therapies. ...
Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net...