近期在Nature上,一篇以“CAR-T cell design: approaching the elusive AND-gate”为题的文章中,Tousley等人设计了逻辑门控胞内网络CAR(LINK CAR、图a),该系统使用近端信号分子与膜结合的抗原结合域(如单链可变片段scFvs)融合,通过共同识别两种抗原来实现...
This new ZAP-70KIDB CAR design uses an intracellular structure containing a native linker, interdomain B, and kinase domains of Zap-70 with exclusion of the SH2 domain. Key T cell proximal (PLCγ1 and SLP-76), distal (AKT and ERK) and NFκB signaling activation studies show that ZAP-...
2024年11月11日， 北京大学深圳研究生院、深圳湾实验室曹宇团队在期刊《Nature Communications》上发表了题为“Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies”的研究论文。研究结果表明，团队的CAR-T细胞策略在雌性小鼠中对各种B细胞恶性肿瘤...
CAR T-cell design: a long road aheaddoi:10.1016/S2352-3026(18)30023-1The Lancet Haematology
1. Chimeric antigen receptornatural killer (CAR-NK) cell design and engineering for cancer therapy. JHematol Oncol. 2021; 14: 73. 2. Natural Born Killers: NK Cells in Cancer Therapy. Cancers (Basel). 2020 Jul 31;12(8):2131 3. CAR-macroph...
目前,对CAR-NK细胞的研究越来越多,基于CAR-T细胞治疗的成功经验,以及新技术和新方法的应用,相信CAR-NK细胞治疗一定能够克服种种挑战,为肿瘤治疗带来新的突破。 参考文献: 1. Chimeric antigen receptornatural killer (CAR-NK) cell design and engineering for cancer therapy. JHematol Oncol. 2021; 14: 73. ...
1. Chimeric antigen receptornatural killer (CAR-NK) cell design and engineering for cancer therapy. JHematol Oncol. 2021; 14: 73. 2. Natural Born Killers: NK Cells in Cancer Therapy. Cancers (Basel). 2020 Jul 31;12(8):2131 3. CAR-macrophage: A newimmunotherapy candidate against solid tu...
1.Cappell, K.M., Kochenderfer, J.N. Long-term outcomes following CAR T cell therapy: what we know so far. Nat Rev Clin Oncol 20, 359–371 (2023) 2.Labanieh, L., Mackall, C.L. CAR immune cells: design principles, resistance and the next generation. Nature 614, 635–648 (2023)...
Lim创建了名为Cell Design Labs的公司以转化该技术,后该公司于2017年末由吉利德科学旗下的Kite Pharma收购,平台也随之被纳入该公司的CAR-T开发平台。synNotch受体平台改进CAR-T细胞疗法的潜力在动物实验和一些临床研究中,针对多种肿瘤/癌症(如黑素瘤、乳腺癌、神经母细胞瘤等)得到验证,现已即将走入临床试验阶段。
1. Chimeric antigen receptornatural killer (CAR-NK) cell design and engineering for cancer therapy. JHematol Oncol. 2021; 14: 73. 2. Natural Born Killers: NK Cells in Cancer Therapy. Cancers (Basel). 2020 Jul 31;12(8):2131 3. CAR-macrophage: A newimmunotherapy candidate against solid tu...