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Contextual reprogramming of CAR-T cells for treatment of HER2+ cancersZhifen Yang, Lingyu Li, Ahu Turkoz, Pohan Chen, Rona Harari-Steinfeld, Maggie Bobbin, Ofir Stefanson, Hana Choi, Violena Pietrobon, Bennett Alphson, Angshumala Goswami, Vitaly Balan, Alper Kearney, ...
T cells, as a key component of the adaptive immune system, can be divided into different subgroups based on function, co-receptor expression (CD4 or CD8), trafficking, metabolism, and lifespan, playing a crucial role in fighting cancer due to their potent ability to recognize and eliminate ca...
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Directly reprogramming T-cells in vivo presumably has readthrough to be even more cost effective than allogeneic CAR-T therapy given manufacturing since engineering occurs intra-patient, as opposed to external manufacturing facilities, and with patient access potentially equivalent to BsAbs. Should it ...
A key obstacle to CAR-NK cell therapy is genetic modification of primary NK cells to achieve stable CAR expression. For CAR-T cell manufacturing, transduction with a viral vector that integrates the CAR-expressing cassette randomly into the genome for persistent expression has been commonly used. ...
KEY FINDINGS The report has the following key findings: The global CAR T-cell therapy market accounted for $734 million in 2019 and is estimated to reach $4,078 million by 2027, registering a CAGR of 23.91% from 2020 to 2027. By approach type the autologous segment was valued at $655.26...
T cells, as a key component of the adaptive immune system, can be divided into different subgroups based on function, co-receptor expression (CD4 or CD8), trafficking, metabolism, and lifespan, playing a crucial role in fighting cancer due to their potent ability to recognize and eliminate ca...
(DNMT3A) gene can inhibit the methylation of several key genes, such as TCF7 and LEF1, which regulate human T cell differentiation. This enables CAR T-cells to maintain memory and proliferative capacity under prolonged antigen exposure, exhibiting sustained cytotoxicity against chronic tumors in ...