regulated by heat shock was reversible and can be terminated simply through switching off the iWarm to avoid the unwanted side effects, such as cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome that are commonly encountered in other cell therapies, such as CAR-T ...
Boosting T cell activation through costimulation directs defense against cancer and viral infections. Despite multiple studies targeting costimulation in clinical trials, the increased potency and reprogramming of T cells endowed by costimulation is poor