体外获能成熟(CAPA-IVM)是一种不经过或经过极少量卵巢刺激后恢复的卵母细胞体外成熟的新方法,该方法在卵母细胞体外成熟过程中纳入了获能步骤,可增强卵母细胞的生长能力。CAPA-IVM是一种患者友好型辅助生殖技术方法,可能成为常规卵巢刺激和IVF的替代方案,从而减轻患者的治疗负担。
This study aimed to determine temporal effects of the pre-IVM phase of CAPA-IVM on cumulus function and oocyte developmental competence in mildly-stimulated mice.Zhao, Y.Liao, X.Krysta, A. E.Bertoldo, M. J.Richani, D.Gilchrist, R. B....
CAPA-IVM yielded significantly (p < 0.0001) less GV-arrested oocytes and larger oocyte diameters (p < 0.05) than STD IVM. Conclusions CAPA-IVM brings significant improvements in maturation and embryological outcomes, most notably to oocytes from small antral follicles (< 6 mm), which can be ...
CAPA-IVM yielded significantly (p < 0.0001) less GV-arrested oocytes and larger oocyte diameters (p < 0.05) than STD IVM. Conclusions CAPA-IVM brings significant improvements in maturation and embryological outcomes, most notably to oocytes from small antral follicles (< 6 mm), which can be ...
Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral folliclesIVFIVMEmbryoOocyte prematurationC-type natriuretic peptidePurpose To investigate the effectiveness of a biphasic IVM culture strategy at improving IVM outcomes in oocytes from small...
significantly lower multiple pregnancy rate as compared to day-3 embryo transfer group (4.6% vs. 18.0%; p=0.005, respectively).#Conclusions: Blastocyst transfer had comparable live birth rate but lower multiple pregnancy rate to day-3 embryo transfer after the first FET following CAPA-IVM in ...
Low oxygen tension resulted in a lower maturation rate and two-pronuclei fertilization rate compared with air oxygen tension in the CAPA-IVM culture. WHAT IS KNOWN ALREADY. CAPA-IVM, with a pre-maturation step, improves the competence of oocytes matured in-vitro. The current CAPA-IVM culture ...