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Finally, as G266 and ZFTMA are immortalized cell lines, it is possible that some of the found epigenetically regulated genes are involved in tumorgenesis, particularly when taking into account that (i) DNA methylation deregulation is common in cancer57 and (ii) AZA-treatment has been shown to...
The cells were fixed and permeabilized, and the proximity ligation was performed following the manufacturer’s protocol using specific primary antibodies described above. Actin filaments were stained with Alexa Flour 488-conjugated phalloidin (A12379; ThermoFisher Scientific) for 30 min. Red foci inside...
Two studies of eIF4E3 mutation or elimination have identified tumor suppressor activity attributable to the Trp/Cys cap-binding contacts [80,82]. Pertinent to virologists, physiological or drug-induced mTOR inhibition downregulates eIF4E, but does not necessarily eliminate cap-dependent translation ...