功能 蛋白质的翻译一般都是cap-binding complex募集43S核糖体复合物到mRNA 5’末端帽子结构,但是存在一些转录本能够通过cap-independent translation起始蛋白质翻译,有研究发现,mRNA 5’UTR区域存在时,能够通过cap-independent translation起始蛋白质翻译。5' UTR可以直接结合eIF3(eukaryotic initiation factor 3),eIF3足以募...
One of the most important mediators of7mGfunctionsisCBC(cap-bindingcomplex).CBChasakeyrolein several gene expression mechanisms, including transcription,splicing,transcriptexportandtranslation.Geneexpressioncanberegulated by signalling pathways which inf l uence CBC function.The aim of the present review ...
TranslationGallie D.R. The role of the poly(A) binding protein in the assembly of the cap-binding complex during translation initiation in plants. Translation. 2014; 2 :e959378.Gallie, D.R. ( 2014 ). The role of the poly(A) binding protein in the assembly of the cap-binding complex...
The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast In eukaryotes, the m(7)GpppN cap structure is added to all nascent RNA polymerase II transcripts, and serves important functions at multiple steps of RNA m... BJ Baron,T Inada,T Preiss,....
To decipher the molecular bases governing seed germination, this study presents the pivotal role of the cap-binding complex (CBC), comprising CBP20 and CBP80, in modulating the inhibitory effects of abscisic acid (ABA) in barley. Using both single and double barley mutants in genes encoding the...
The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway fo...
To decipher the molecular bases governing seed germination, this study presents the pivotal role of the cap-binding complex (CBC), comprising CBP20 and CBP80, in modulating the inhibitory effects of abscisic acid (ABA) in barley. Using both single and do
associated with increased recruitment of eukaryotic translation initiation factor 4E-binding protein (4E-BP) 1 in the translational complex, which was revealed by 7-methyl-cap-binding assays, suggesting inhibition of cap-dependent translation... K Vishnoi,R Ke,KS Saini,... - 《Molecular Pharmacolog...
21). We previously reported that human Y14 interacts with the decapping complex and inhibits the activity of Dcp2 (22). The eukaryotic translation initiation factor 4E (eIF4E) competes with Dcp1 for binding to the cap structure and inhibits the decapping activity of Dcp2, whereby it prevents...
CBC is a multifaceted complex essential for gene expression, which integrates RNA processing events, transcript nuclear export and translation. IDENTIFICATION OF CBC AS A NUCLEAR CAP-BINDING COMPLEX CBC was first purified from nuclear extracts of HeLa cells on the basis of its affinity for ...