THCEndocannabinoidsHeroinCannabis dependenceCo-abuseEndorphinEnkephalinDynorphinPENKThe growing use of cannabis in western societies is of significant concern especially considering that its consumption has increased in teens who are most at risk for developing addictive disorders and other psychiatric illnesses ...
Dmitry B. Veprintsev, Thomas Boesen, Jette S. Kastrup & David E. Gloriam 5928 Accesses 7 Altmetric Explore all metrics Abstract Tetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions, appetite stimulati...
BackgroundThe approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management of treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity for many patients. The aim of our study was to describe Sativex effectiveness and adverse ...
Semus, S. F.; Martin, B. R. A computer graphic investigation into the pharmacological role of the THC-cannabinoid phenolic moiety. Life Sci. 1990, 46, 1781-1785.Semus S. F. and Martin B. R. (1990) A computergraphic investiga- tion into the pharmacological role of the THC-...
(B) Quantification of the surface area occupied by AMH-positive cells (AMH +) after CBD and/or THC treatment at 10−5 M compared to respective control in 8–10 and 10–12 DW embryonic testis. Representative immunostaining of AMH, a specific marker of Sertoli cell, in explants of an ...
Intracerebroventricular administration of a nor-binaltorphimine or b AM630 on the central antinociception produced by PnPP-19. Nor-binaltorphimine (Nor-Bni; 10 and 20 μg) or AM630 (2 and 4 μg) was administered 1 min prior to PnPP-19 (1 μg) injection. These antagonists did not...
b Trial Part 2 (randomised). CBD cannabidiol, THC, Δ9-tetrahydrocannabinol. Full size image Part 2 Twenty-one patients were randomised in Part 2 of the trial; 12 received nabiximols and nine received placebo, and all were included in the safety analysis. The mean age was 57.8 years in ...
(B) THC, or (C) a mixture of CBD/THC (ratio 1:1). Results are expressed related to the amount of testosterone produced during the first 24 h of culture (D0) and as fold from the respective control. Data are means + / − SEM. An ANOVA test was performed followed by ...
(diastereomer B, faster eluting enantiomer), (28) 2,2,2-trifluoro-1-(3-(trifluoromethyl)-5-{[4-({2-[4-(trifluoromethyl)phenyl]cyclopropyl}carbonyl)piperazin-1-yl]sulfonyl}phenyl)ethanol (diastereomer B, slower eluting enantiomer), (29) 1-{[3-(3-methyl-1H-pyrazol-4-yl)-5-(...
Delta-9-tetrahydrocannabinol or Delta-9 THC, the principle active component of Cannabis sativa (marijuana), is a member of a large family of lipophilic compounds (i.e., cannabinoids) that mediate physiological and psychotropic effects including regulation of appetite, immunosuppression, analgesia, ...