Haematological malignancies are a diverse set of conditions affecting the blood, bone marrow and lymphatic system and make up approximately j% of all cancers in the UK. They include multiple myeloma, lymphomas and leukaemias.They may be aggressive diseases that require treatment with intensive ...
Diagnosis: The diagnosis of multiple myeloma typically involves a comprehensive approach, including a full blood count (FBC), bone marrow studies and imaging tests like X-rays, MRI and PET/CT scans. These diagnostic tools help medical professionals assess the full s...
Our leadership has advanced transformative therapies for hematologic malignancies, and we are committed to continuing to lead in the evolution of our understanding and treatment of these diseases. MULTIPLE MYELOMA Until recently, treatment of multiple myeloma, the second most common blood cancer, had ...
decision-making processes regarding end-of-life (EOL) care.Between September 2013 and January 2014, 20 hematologic oncologists from the Dana-Farber/Harvard Cancer Center participated in four focus groups regarding EOL care for leukemia, lymphoma, multiple myeloma, and hematopoietic stem-cell ...
Cancer is a life-altering event causing considerable psychological distress. However, information on the total burden of psychiatric disorders across all common adult cancers and therapy exposures has remained scarce. Here, we estimated the risk of self-
Such studies suggest increased risks of several cancers, especially Hodgkin disease, anal cancer, seminoma, myeloma, and, less certainly, cancers of the lip, brain and lung (Goedert et al, 1998; Frisch et al, 2001; Grulich et al, 2002). The evaluation by IARC (1997) considered that the...
Multiple myeloma is one of the most common forms of blood cancer. Yang said that DARA, while proven effective as a combination treatment, is not always successful for high-risk patients with multiple myeloma. Yang and team found that patients express the NHE6 protein at elevated rates, and ...
Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression, dev
Cell-free DNA (cfDNA) from blood plasma represents an alternative source of DNA for tumor profiling53. Recently, cfDNA NGS profiling including WGS has been used to detect tumor-specific CNAs and fragmentation patterns in pediatric tumors54,55,56. However, the potential of high-depth WGS in ...
The three major types of HC are the leukemias, the myelomas, and the lymphomas. Leukemias are "liquid" tumors in the blood derived from the transformation of either a hematopoietic precursor in the bone marrow or a mature hematopoietic cell circulating in the blood. In myelomas, the ...