Fourthly, the treatment landscape has expanded from monotherapy to combination therapies, encompassing a variety of immunomodulators, anti-angiogenic drugs, chemotherapies, and targeted therapies. Lastly, a diverse array of treatments, including previously ‘undruggable’ targets, peptide drugs, monoclonal a...
Besides intratumoral injection, several nanotherapeutic systems can also be surgically implanted at or near tumor sites for the direct elimination of solid tumors, or at tumor resection sites for the prevention of cancer recurrence.147,149A DOX-loaded nanofibrous membrane that was implanted on the top...
Although notable progress has been made on novel cancer treatments, the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients. Chemoimmunotherapy, combining chemotherapeutics and immunotherapeutic drugs, has emerged as a promising approach for cancer treatment, with the a...
Besides, except for the high-dose group, the body weight of mice was maintained stable, and the state of mice was normal. Conclusions In this study, we proved CD276 CAR-T exhibited powerful activity against pancreatic cancer cells in vitro and in vivo. More importantly, we demonstrated the ...
Many cancers adapt to chemo- and radiation therapy: according to some researchers, the clonal selection leads to the resistance of recurrent tumors [36]. If “cancer-embryos” are nurtured in various conditions before they proceed to active life-cycling, they might give birth to distinct “...
[194,195]. Besides, the DNA nanorobot can perform Boolean logic operations on the cancer cell membrane and has a great theranostic potential to be used in clinical treatment of cancers. Dolev et al. [196] designed a nanorobot that could detect circulating cancer cells in the blood and expose...
nivolumab combined with chemotherapy also improved OS (13.8 vs. 11.6 months; HR 0.80; 99.3% CI, 0.68 to 0.94;P = 0.0002). Moreover, all CPS subgroups exhibited an increased objective response rate in the nivo-chemotherapy arm. However, the chemo-free treatment with nivolumab and ipilimuma...
Besides, cyanine conjugates that serve as nanocarriers for drug delivery are introduced as well. In an additional section, we analyze the potential of these conjugates for clinical translation. Overall, this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and ...
Introduction Cancer is a significant public health issue with a rapidly growing incidence and mortality worldwide,1leading to about 10 million deaths annually.2Chemotherapy is presently one of the most common anti-cancer treatments due to its high efficiency currently.3,4However, its lack of selecti...
Older patients seem to be more at risk of post chemo cognitive impairment compared to younger patients. If oestrogen and testosterone are depleted as well, such as with breast and prostate cancer treatments, the mental impairment is worse. Ongoing anxiety and depression also worsen the condition. ...