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, 37.]. Probiotic bacteria can serve as safer alternatives, but they lack the innate therapeutic potency of tumor-targeting bacteria. Another limitation of bacteria-based therapies is their inability to completely eradicate tumors on their own [19,20], requiring assistance from conventional therapies...
38Such models have adeptly mirrored the feasibility of tumoroids in the accurate recapitulation of KRAS-mutant metastatic rectal cancer with microsatellite stability after hepatic resection and treatment with neoadjuvant combination chemotherapies in colorectal cancer (CRC),39as well as gauged...
Chemotherapy represents one of the main alternatives for cancer treatment, employing a wide group of drugs, including specific molecules capable of inhibiting proliferativesignaling pathways, replicative immortality mechanisms, and angiogenesis, as well as inducing the apoptosis of tumor cells[7]. ...
Antibody-drug conjugates (ADCs) are one of fastest growing classes of oncology drugs in modern drug development. By harnessing the powers of both cytotoxic chemotherapy and targeted therapy, ADCs are unique in offering the potential to deliver highly pot
reducing the quality and length of their lives, the time has come to look for safe, effective, affordable, inexpensive and accessible alternatives to patented chemicals and ionizing radiation in the prevention and treatment of cancer. And the solution may be as close to us as our kitchen spice...
For tumor progression, treatment alternatives will be evaluated and discussed interdisciplinary considering options of surgical resection, systemic treatment such as chemotherapy, a third course of radiation therapy, or other. Statistical considerations This section describes the considerations underlying the cho...
The challenge is thus to assess, on a case-by-case basis, the trade-off between delayed diagnosis and treatment of cancer and exposure to SARS-CoV-2. Limiting the risk of COVID-19 infection in cancer patients To limit the risk of SARS-CoV-2 contamination and the risks associated with ...
The regulatory mechanism of ferroptosis is closely related to the processes of lipid peroxidation and iron accumulation. Due to the iron dependence of tumour cells, therapeutic strategies that target ferroptosis in recent years have provided new therapeutic opportunities for the treatment of refractory ...