Ciclopirox olamine (Santa Cruz Biotechnology, Dallas, TX, USA); antimycin A (Sigma-Aldrich); rotenone (MP Biomedicals, Santa Ana, CA, USA); metformin (Enzo Life Sciences, Lörrach, Germany); deferasirox (LKT Laboratories, St. Paul, MN, USA); deferoxamine mesylate (Sigma-Aldrich); dichloroa...
1). Given the recent meta-analysis of exome data from the TCGA Pan-Cancer Atlas23,24,25, scientific working groups concentrated their efforts on analyses best-informed by whole-genome sequencing data. We collected genome data from 2,834 donors (Extended Data Table 1), of which 176 were ...
Protocatechuic acid was purchased from LKT Labs (St. Paul, MN). Purified tubulin protein was purchased from Cytoskeleton (Denver, CO). Phenol-red free matrigel was obtained from Corning (Bedford, MA). DMSO, ethanol, and trichloroacetic acid were obtained from Thermo Fisher Scientific (Waltham, ...
She has served on the Boards of Trustees for the Chicago Medical Society and the Illinois State Medical Society and has chaired various advocacy groups through these organizations. Dr Fidler joined the BMC Cancer as Editorial Board and serves as Senior Board Member since August 2020.Niccola Funel...
Regulatory T cells (Treg cells), M2macrophages and memory T cells mainly rely on FAO (fatty acid oxidation)-sourced OXPHOS for energy supply. There is clear data from several groups that perturbing the OXPHOS of immune cell can inhibit its functions [134]. For instance, resting NK cells dep...
Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and...
This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for colorectal cancer summarizes
Financial support to the AOCS was provided by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, the Cancer Council Tasmania and Cancer Foundation of Western Australia. ABS and GCT are Senior and Senior Principal Research Fellows, respectively, of the NHMRC. The MCCS...
Anaplastic thyroid cancer (ATC) is a highly aggressive type of thyroid cancer (TC). Currently, no effective target treatments are available that can improve overall survival, with ATC representing a major clinical challenge because of its remarkable leth
Culture supernatants from activated human monocytes, which support ovarian tumor growth, contained significant amounts of IL-6, and anti-IL-6 serum inhibited part of this monocyte-produced growth-supporting activity.37 Therefore, IL-6 has the potential to act as a paracrine growth factor for ...